Akt

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Akt

One of the main downstream targets of the PtdIns(3,4,5)P3 signaling pathway is the serine/threonine protein kinase Akt/PKB (Protein Kinase B), which has antiapoptotic activity. It has a pleckstrin homology (PH) domain that binds PtdIns(3,4,5)P3 on the plasma membrane in a particular way. The amount of PtdIns(3,4,5)P3 on the plasma membrane, which is controlled by PI3K, directly affects Akt phosphorylation and activation.

There are three isoforms of Akt: PKB/Akt1, PKB/Akt2, and PKB/Akt3. The PH (pleckstrin homology) domain and the kinase domain of the Akt isoforms are separated by a 39-amino-acid hinge region. Numerous substrates involved in cell survival, growth, proliferation, metabolism, and protein synthesis are controlled by catalytically active Akt.
A key mediator of cell survival, Akt, is deactivated in a number of diseases that involve pathological cell death brought on by stress.

Akt related products

Cat No.	Product Name	CAS No.	Product Description
V85001	Isomaltulose monohydrate	58024-13-8
V84682	JE-133	2579171-69-8
V33314	K-80003	1292821-90-9	K-80003 effectively inhibits tRXRα-dependent Akt activation and tumor cell growth.
V3318	Miransertib HCl (ARQ 092; MK-7075)	1313883-00-9	Miransertib HCl (formerly known as ARQ-092; MK7075), the HCl salt ofMiransertib, is a novel, orally bioactive and selective allosteric inhibitor of AKT anticancer activity.
V0155	MK-2206 2HCl	1032350-13-2	MK-2206 dihydrochloride (2HCl) is a novel, potent, orally bioavailable and highly selective allosteric inhibitor of the serine/threonine protein kinase Akt1/2/3 with potential anticancer activity.
V25651	ML 9 HCl salt	105637-50-1	ML-9 HCl is a novel, potent and selective myosin light chain kinase (MLCK) inhibitor, also Akt kinase andand stromal interaction molecule 1 (STIM1).
V70204	Monomethyl lithospermate (Lithospermic acid monomethyl ester)	933054-33-2	Monomethyl lithospermate activates the PI3K/AKT pathway and exerts a protective effect on nerve damage.
V82333	N1,N8-Diacetylspermidine hydrochloride	178244-42-3	N1,N8-Diacetylspermidine HCl is a polyamine found in human urine.
V98037	NAP1051	864516-77-8	NAP1051 is a biomimetic analog of lipid A4 that achieves antitumor effects by targeting the inflammatory tumor microenvironment.
V103672	PD-1/PD-L1-IN-54	1393644-68-2	PD-1/PD-L1-IN-54 (Compound 6) is a moderate affinity PD-1/PD-L1 inhibitor (KD: PD-1, 55.8 μM; PD-L1, 46.4 μM; IC50: 88.6 μM).
V0123	PF-04691502	1013101-36-4	PF-04691502 is a novel, potent, ATP-competitive and selective dual inhibitor of PI3K (phosphatidylinositol 3 kinase) and mTOR (mammalian target of rapamycin) with potential anticancer activity.
V4482	PF-AKT400	1004990-28-6	PF-AKT400 (AKT-0286; ZINC-111606147), designed based on a 3-aminopyrrolidine scaffold, is a novel, selective, potent, ATP-competitiveAkt kinase inhibitor with antitumor activity.
V0165	PHT-427 (CS-0223)	1191951-57-1	PHT-427(CS0223) is a novel, potent, orally bioactive and dual inhibitor of Akt and PDPK1 (PtdIns dependent protein kinase-1) with potential anticancer activity.
V78942	PI3K-IN-48		PI3K-IN-48 is a PI3K inhibitor (antagonist) with IC50 of 1.55 ± 0.18 μM on A549 cells.
V70209	Reptoside	53839-03-5	Reptoside is an iridoid glycoside that is a DNA damaging agent.
V0074	SC66	871361-88-5	SC66 is a novel, potent and allosteric inhibitor of AKT with potential anticancer activity, itreduces cell viability in a dose- and time-dependent manner, inhibits colony formation and induces apoptosis in hepatocellular carcinoma (HCC) cells.
V0171	SC79	305834-79-1	SC79 is a novel, potent,selective, cell-permeable, and brain-penetrable activator of Akt phosphorylation with the potential to be used to enhance Akt activity in various physiological and pathological conditions, e.
V15181	SPP-86	1357349-91-7	SPP-86 is a potent and selective inhibitor of RET tyrosine kinase with IC50 of 8 nM.
V83930	SQLE-IN-1	1019169-83-5
V56156	Tanshinol borneol ester	1623012-10-1	Tanshinol borneol ester is an angiogenesis stimulator that promotes multiple key steps of angiogenesis through the Akt and MAPK signaling pathways.