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RSK

RSK

Ribosomal S6 Kinase (RSK) is a family of serine/threonine protein kinases involved in the regulation of cell viability.In response to mitogens, RSK is phosphorylated by the activation of one or more protein kinase cascades. The 70 kDa and 90 kDa S6 kinase families, which can be distinguished by size, are the two distinct mitogen-activated S6 kinase families that phosphorylate S6 in vivo. The activation of both S6 kinases occurs through serine/threonine phosphorylation.

The Ras/Raf/MEK/ERK signaling pathway's downstream effectors are members of the highly conserved Ser/Thr kinase family known as p90 ribosomal s6 kinase (1-4). They control a variety of cellular functions, including cell growth, motility, survival, and proliferation. AGC family member and key player in the mTOR signaling cascade is the p70 ribosomal protein S6 kinase.It is a multifunctional Ser/Thr kinase. Numerous cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth, and apoptosis are closely correlated with the p70 ribosomal protein S6 kinase.

RSK related products

Structure Cat No. Product Name CAS No. Product Description
AD57 hydrochloride V69552 AD57 hydrochloride 2320261-72-9 AD57 is an orally bioactive multikinase inhibitor that can suppress RET, BRAF, S6K, and Src activities.
BIX 02565 V6571 BIX 02565 1311367-27-7 BIX 02565 is a novel RSK2 inhibitor with IC50 of 1 nM.
CMK V29201 CMK 821794-90-5 CMK is an RSK2 kinase inhibitor (antagonist) with similar potency but lower chemical stability than FMK.
Coronarin A V70259 Coronarin A 119188-33-9 Coronarin A is an orally bioactive naturally occurring compound that can inhibit mTORC1 and S6K1 and increases IRS1 activity.
HSND80 V137589 HSND80 HSND80 is an orally effective MNK/p70S6K inhibitor with Kd values of 44 nM for MNK1 and 4 nM for MNK2.
Inactone V137914 Inactone 487-34-3 Inactone is a bioactive molecule containing a 3-glutarimide group that inhibits the large ribosomal subunit.
LJH685 V24250 LJH685 1627710-50-2 LJH685 is a potent, selective, ATP-competitive RSK inhibitor that can suppress RSK1/2/3 bioactivity with IC50 of 6, 5, and 4 nM.
Multi-kinase-IN-12 V140504 Multi-kinase-IN-12 597544-21-3 Multi-kinase-IN-12 is a non-selective multi-target inhibitor with the following IC50 values for human targets: Flt3 < 0.001 μM, c-Src 0.002 μM, KDR 0.004 μM, Eph-A2, MNK-1 and Flt1 0.011 μM, Lck 0.016 μM, Rsk1 0.21 μM, and AMPK α2 subunit 0.041 μM.
Pluripotin (SC1) V2667 Pluripotin (SC1) 839707-37-8 Pluripotin (also known as SC1; SC-1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP as well as asustainer of mES self-renewal.
RSK-IN-2 V144396 RSK-IN-2 3011713-80-4 RSK-IN-2 is an RSK inhibitor with IC50 values of 37.89 nM (RSK2), 30.78 nM (RSK1), 20.51 nM (RSK3), and 91.28 nM (RSK4).
RSK2-IN-4 V144395 RSK2-IN-4 62001-32-5 RSK2-IN-4 is an RSK2 inhibitor that inhibits RSK2 activity by 13.73% at a concentration of 10 μM.
RSK2-IN-5 V120331 RSK2-IN-5 799832-19-2 RSK2-IN-5 (compound C24) is a p90 ribosomal S6 kinase 2 (RSK2) inhibitor with a Kd value of 317 nM.
RSK2-IN-6 V119921 RSK2-IN-6 304474-86-0 RSK2-IN-5 (compound C2) is a p90 ribosomal S6 kinase 2 (RSK2) inhibitor with a Ki value of 856 nM.
RSK2/TOP2-IN-1 V118311 RSK2/TOP2-IN-1 RSK2/TOP2-IN-1 is a dual inhibitor of RSK2 and TOP2.
RSK4-IN-1 V74151 RSK4-IN-1 2755819-10-2 RSK4-IN-1 has potent RSK4 inhibitory activity with IC50 of 9.5 nM.
RSK4-IN-1 TFA V100258 RSK4-IN-1 TFA RSK4-IN-1 TFA is a potent RSK4 inhibitor with IC50 of 9.5 nM.
RSK4-IN-2 V109978 RSK4-IN-2 3034203-03-4 RSK4-IN-2 (compound 16o) is a potent, orally active RSK4 inhibitor with an IC50 value of 17 nM.
S6 Kinase Substrate Peptide 32 V81345 S6 Kinase Substrate Peptide 32 S6 Kinase Substrate Peptide 32 is a substrate for Ribosomal S6 Kinase (RSK) and may be utilized to measure the kinase activity of RSKs that phosphorylates ribosomal protein S6.
S6K Substrate acetate V144481 S6K Substrate acetate S6K Substrate acetate is a substrate for active protein kinases, including CLK2, MRCKalpha, MRCKbeta, p70S6K, ROCK1, ROCK2, RSK1, RSK3, and PIM1.
SL0101 V4446 SL0101 77307-50-7 SL0101 (SL 0101-1) a kaempferol glycoside isolated from the tropical plant F. refracta, is a novel, potent, cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM.
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