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    SL0101
    SL0101

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4446
    CAS #: 77307-50-7Purity ≥98%

    Description: SL0101 (SL 0101-1) a kaempferol glycoside isolated from the tropical plant F. refracta, is a novel, potent, cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. It shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase. SL0101 showed improved in vitro biological stability while maintaining specificity for RSK. These results should facilitate the development of RSK inhibitors derived from SL0101 as anticancer agents.  

    References: Cancer Res. 2005 Feb 1;65(3):1027-34.


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    SL0101

    Name: SL0101
    CAS#: 77307-50-7
    Chemical Formula: C25H24O12
    Exact Mass: 516.12678
    Molecular Weight: 516.45
    Elemental Analysis: C, 58.14; H, 4.68; O, 37.18
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: SL0101; SL0101; SL 0101; SL 0101-1; SL-0101-1; SL0101-1
    IUPAC/Chemical Name: (2S,3S,4S,5R,6S)-6-((5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl)oxy)-5-hydroxy-2-methyltetrahydro-2H-pyran-3,4-diyl diacetate
    InChi Key: SXOZSDJHGMAEGZ-IGKKHSBFSA-N
    InChi Code: InChI=1S/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21-,24-,25-/m0/s1
    SMILES Code: C[[email protected]]1[[email protected]](OC(C)=O)[[email protected]@H](OC(C)=O)[[email protected]@H](O)[[email protected]](OC2=C(C3=CC=C(O)C=C3)OC4=C(C(O)=CC(O)=C4)C2=O)O1


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