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Mixed Lineage Kinase

Mixed Lineage Kinase

Mixed lineage kinases (MLKs) control the c-Jun N-terminal kinase (JNK), mitogen activated protein kinase (MAPK), and extracellular signal-regulated kinase (ERK) signaling cascades. They are mitogen activated protein kinase kinases (MAPKKKs) with features of both serine-threonine and tyrosine kinases.

The most abundantly expressed member of the MLK family, MLK3 (MAP3K11), is found in neurons as well as other cell types. Stress, such as that caused by reactive oxygen species, ceramide, and TNF, activates MLK3 on a cellular level. It is triggered at the molecular level by Cdc42 and Rac, which engage MLK3 and can dimerize it via a leucine zipper interface, leading to autophosphorylation and enzyme activation.

Mixed Lineage Kinase related products

Structure Cat No. Product Name CAS No. Product Description
Anticancer agent 267 V128960 Anticancer agent 267 Anticancer agent 267 is an activator of RIPK3 and MLKL.
Biotin-MLK1 Recombinant Human Active Protein Kinase V118888 Biotin-MLK1 Recombinant Human Active Protein Kinase MLK1 is a kinase that phosphorylates the threonine residue at position 3 of H3 and participates in osmotic stress responses.
Biotin-MLK2 Recombinant Human Active Protein Kinase V118944 Biotin-MLK2 Recombinant Human Active Protein Kinase MLK2 is a kinase that phosphorylates the threonine residue at position 3 of H3 and participates in osmotic stress responses.
Famlasertib V135741 Famlasertib 2375591-69-6 Famlasertib is a potent, blood-brain barrier-crossing MAP4K inhibitor with IC50 values of 0.3 nM, 23.7 nM, and 44.7 nM for HGK (MAP4K4), MLK3, and MLK1, respectively.
GNE-3511 V2799 GNE-3511 1496581-76-0 GNE-3511 is a novel, highly potent and selective zipper kinase (e.g. DLK, MAP3K12) inhibitor with IC50 of 0.107 uM for DLK.
GW806742X V4944 GW806742X 579515-63-2 GW806742X is a novel and potent inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain with aKdvalue of 9.3 μM and has anti-necroptosis activity.
GW806742X hydrochloride V76946 GW806742X hydrochloride GW806742X HCl is an ATP mimetic and a potent MLKL inhibitor that binds to the MLKL pseudokinase domain with a Kd of 9.3 μM.
MBA-m1 V139480 MBA-m1 305866-70-0 MBA-m1 is an MLKL inhibitor.
MLK-IN-1 V74095 MLK-IN-1 1627729-62-7 MLK-IN-1 is a potent brain-penetrating specific MLK-3 inhibitor, compound 68 obtained from patent US20140256733A1.
MLK-IN-2 V83497 MLK-IN-2 2614255-51-3
MLK3-IN-1 V105078 MLK3-IN-1 MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of <1 nM.
MLKL ligand-2 V140041 MLKL ligand-2 MLKL ligand-2 is a hybrid lineage kinase domain-like pseudokinase (MLKL) PROTAC ligand with a KD value of 9.408 μM.
MLKL-IN-1 V74098 MLKL-IN-1 2837019-30-2 MLKL-IN-1 is a covalent MLKL inhibitor (antagonist) with Kd of 50 μM.
MLKL-IN-2 V74097 MLKL-IN-2 899759-16-1 MLKL-IN-2 is an inhibitor (blocker/antagonist) of MLKL.
MLKL-IN-3 V80790 MLKL-IN-3 3031406-27-3 MLKL-IN-3 (compound 66) is a potent inhibitor of MLKL (mixed lineage kinase domain-like protein).
MLKL-IN-5 V74099 MLKL-IN-5 2755872-58-1 MLKL-IN-5 is a potent MLKL inhibitor that mediates necroptosis.
MLKL-IN-6 V79876 MLKL-IN-6 MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL).
MLKL-IN-7 V87088 MLKL-IN-7 MLKL-IN-7 (compound 9) is a MLKL inhibitor, exhibits anti-necroptotic activity in HT-29 cells with IC50 value of 148.4 nM.
Necrosulfonamide HCl V34662 Necrosulfonamide HCl 432531-71-0 NecrosulfonamideHCl is a potent andcell-permeable MLKL (mixed lineage kinase domain-like) inhibitor.
Necrosulfonamide-d4 V74096 Necrosulfonamide-d4 1795144-22-7 Necrosulfonamide-d4 is the deuterated form of Necrosulfonamide.
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