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CID-5951923 (CID5951923) is a novel and potent inhibitor of Kruppel-like factor 5 (KLF5) expression (IC50 of 603 nM) with anticancer activity. Compound CID 5951923 was found to be specifically effective against colon cancer cells when tested in the NCI-60 panel of human cancer cell lines.
| Targets |
MEK5 (IC50 = 1.5 nM); ERK5 (IC50 = 59 nM); CSF1R (FMS) (IC50 = 46 nM); LCK (IC50 = 250 nM); JAK3 (IC50 = 440 nM); TGFβR1 (IC50 = 580 nM); RPS6KA6 (RSK4) (IC50 = 990 nM); RPS6KA3 (RSK2) (IC50 = 2.1 μM); FGFR1 (IC50 = 1 μM); KIT (IC50 = 1.1 μM); ABL1 (IC50 = 2.4 μM); MAPK14 (p38 alpha) (IC50 = 3.7 μM); SRC (IC50 = 7.6 μM)
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| ln Vitro |
CID 5951923 (1 nM-100 μM; 48 h) inhibits DLD-1 cell proliferation in a dose-dependent manner[1].
CID 5951923 (10 μM; 24 h) significantly lowers endogenous KLF5 levels in DLD-1 cells, raises pEGFFpY1068 phosphorylation levels, and suppresses EGR1[1]. CID 5951923 (10 μM) inhibits the growth of cancer cell lines, primarily in KLF5-expressing cells[1]. |
| References |
| Molecular Formula |
C16H18N2O7S
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|---|---|
| Molecular Weight |
382.38832
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| Exact Mass |
382.08
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| Elemental Analysis |
C, 50.26; H, 4.74; N, 7.33; O, 29.29; S, 8.38
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| CAS # |
749872-43-3
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| Related CAS # |
749872-43-3
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| Appearance |
Solid powder
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| SMILES |
CN(C1CCS(=O)(=O)C1)C(=O)COC(=O)/C=C/C2=CC(=CC=C2)[N+](=O)[O-]
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| InChi Key |
URVRJYLSUVXWBC-AATRIKPKSA-N
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| InChi Code |
InChI=1S/C16H18N2O7S/c1-17(14-7-8-26(23,24)11-14)15(19)10-25-16(20)6-5-12-3-2-4-13(9-12)18(21)22/h2-6,9,14H,7-8,10-11H2,1H3/b6-5+
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| Chemical Name |
[2-[(1,1-dioxothiolan-3-yl)-methylamino]-2-oxoethyl] (E)-3-(3-nitrophenyl)prop-2-enoate
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| Synonyms |
CID5951923; CID-5951923; CID 5951923
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| HS Tariff Code |
2934.99.03.00
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~88 mg/mL (~199.8 mM)
Ethanol: ~88 mg/mL(~199.8 mM) |
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| Solubility (In Vivo) |
2% DMSO+30% PEG 300+5% Tween 80+ddH2O: 10mg/mL (Please use freshly prepared in vivo formulations for optimal results.)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6151 mL | 13.0757 mL | 26.1513 mL | |
| 5 mM | 0.5230 mL | 2.6151 mL | 5.2303 mL | |
| 10 mM | 0.2615 mL | 1.3076 mL | 2.6151 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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