ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V37627 | Sandramycin | 100940-65-6 | Sandramycin is a cyclic decapeptide antibiotic extracted from the culture medium of Nocardioides sp. |
|
V37124 | Seco-DUBA | 1227961-59-2 | Seco-DUBA is a prodrug of docarmycin (DUBA) that contains two hydroxyl groups, each of which can be conjugated to an antibody through a linker. |
|
V53331 | Seco-DUBA hydrochloride | 1795733-93-5 | Seco-DUBA HCl is the toxin molecule of the ADC drug SYD985. |
|
V54467 | Seco-Duocarmycin SA | 144667-38-9 | Seco-Duocarmycin SA is a DNA alkylating agent that works as the toxin part of Antibody-drug conjugates (ADC). |
|
V54469 | Seco-DuocarmycinTM | 236102-87-7 | Seco-Duocarmycin TM is a DNA alkylating agent of the Duocarmycins family that can inhibit DNA synthesis. |
|
V52675 | SN-38-d3 (NK012-d3) | 718612-49-8 | SN-38-d3 is the deuterium labelled form of SN-38. |
|
V52181 | sulfo-DGN462 sodium | 1401203-09-5 | Sulfo-DGN46 sodium can be degraded to DGN462 in culture medium and plasma. |
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V54481 | TAM470 | 1802498-63-0 | TAM470 is a novel cytolysin that can inhibit tubulin aggregation and microtubule depolymerization. |
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V2228 | TST-A | 1426953-21-0 | TST-A, also known as Thailanstatin A, is a potent antiproliferative agent, which was isolated from the fermentation broth of B. |
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V54476 | Tubulysin IM-2 | 1032072-50-6 | Tubulysin IM-2 is a microtubule/tubulin inhibitor that can be used as ADC Cytotoxin and anti-microtubule toxins for ADC synthesis. |
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V54489 | Tubulysin IM-3 | 1639986-05-2 | Tubulysin IM-3 is a microtubule/tubulin inhibitor that can be used as ADC Cytotoxin and anti-microtubule toxins for ADC synthesis. |
|
V51220 | γ-Amanitin | 21150-23-2 | ADC cytotoxin |
|
V51222 | ε-Amanitin | 21705-02-2 | ADC cytotoxin |
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