ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V75825 | Fmoc-MMAF-OMe | 863971-38-4 | Fmoc-MMAF-OMe is an anticancer agent and tubulin polymerization inhibitor (antagonist) with Fmoc protecting group. |
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V54474 | Gly-Cyclopropane-Exatecan | 2414254-49-0 | Gly-Cyclopropane-Exatecan (compound 5c) participates in the synthesis/preparation of anti-B7-H4 antibody active molecular conjugates (ADC), containing the DNA topoisomerase I (Top I) inhibitor Exatecan . |
|
V54487 | Hemiasterlin derivative-1 | 1887046-60-7 | Hemiasterlin analogue-1 is a hemiasterlin analogue. |
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V51961 | Hygrolidin | 83329-73-1 | Hygrolidin is a 16-membered macrolide antibiotic derived from Streptomyces hygroscopicus D-1166. |
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V53423 | Luisol A | 225110-59-8 | Luisol A is an aromatic tetraol that is the major metabolite of estuarine marine actinomycetes of the genus Streptomyces. |
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V51807 | Maytansinoid B | 1628543-40-7 | Maytansinoid B is an ADC Cytotoxin that can be coupled with antibodies to form Antibody-Drug Conjugates (ADCs). |
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V25076 | Maytansinoid DM4 | 796073-69-3 | Maytansinoid DM4, a naturally occuring maytansine analogue, is a highly potent/cytotoxic antitubulin agent with anticancer properties. |
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V17212 | Mertansine (DM1) | 139504-50-0 | Mertansine refers to the thiol-containing maytansinoid, DM1 (N2’-deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with an SPP (N-succinimidyl 4-(2-pyridyldithio)) linker to create an antibody-drug conjugate or ADC. |
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V29041 | MMAF-OMe | 863971-12-4 | MMAF-OMe (Monomethyl auristatin F methyl ester-O-methyl), an auristatin-derived anticancer agent, is a novel and potent warhead used in ADC (antibody-drug conjugate). |
|
V51229 | Modified MMAF | 1352202-47-1 | ADC cytotoxin |
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V41147 | Muscotoxin A | 1653999-47-3 | Muscotoxin A is ADC cytotoxin. |
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V37613 | N-Me-L-Ala-maytansinol | 77668-69-0 | N-Me-La L a-maytansinol is a hydrophobic, cell-penetrating/penetrable payload for the preparation of active antibody conjugates (ADCs). |
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V54472 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT | 2857037-69-3 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT (compound I) is a topoisomerase I inhibitor that can be targeted and delivered to cells through conjugated antibodies and has good ADC activity in vivo and in vitro. |
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V76704 | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride | NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT(compound I) HCl is a topoisomerase I inhibitor that can be targeted and delivered to cells through conjugated antibodies and has good in vitro and in vivo ADC activity. | |
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V54483 | NH2-methylpropanamide-Exatecan TFA | 1817857-35-4 | NH2-methylpropanamide-Exatecan (TFA) is an isobutylamide-modified Exatecan , which is a common ADC toxin (ADC Cytotoxin) and may be used in the synthesis/preparation of ADC. |
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V54480 | NMS-P528 | 1466546-45-1 | NMS-P528 is a Duocarmycin analogue that can be used as an ADC payload. |
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V4152 | PNU-159682 | 202350-68-3 | PNU-159682 (PNU) is a highly potent metabolite of the anthracycline nemorubicin (MMDX)with excellent cytotoxicity. |
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V51211 | PNU-159682 carboxylic acid | 1204819-92-0 | cytotoxin for ADCs |
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V53125 | PROTAC BRD4 Degrader-5-CO-PEG3-N3 | 2704602-92-4 | PROTAC BRD4 Degrader-5-CO-PEG3-N3 (Compound 2) A PROTAC-linker conjugate for PAC, containing the BRD4 degrader GNE-987 and 3 PEG linkers. |
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V53138 | S-Me-DM4 | 890654-03-2 | S-Me-DM4 is a metabolite produced by S-methylation of part of DM4 by intracellular enzymes. |
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