ADC cytotoxins, also referred to as payloads, are cytotoxic substances that cause the death of target cells in ADCs (antibody drug conjugates). A monoclonal antibody, a linker, and a cytotoxin are the components of an ADC, which is a targeted agent. The cytotoxin is the most crucial component because it determines how effective an ADC is at killing cancer cells.
Numerous cytotoxins, including calicheamicins, duocarmycins, pyrrolobenzodiazepines (PBDs), camptothecins, daunorubicins/doxorubicins, auristatins, and maytansinoids, are currently in use. Based on how they work, they can be classified as either DNA-damaging agents or tubulin inhibitors. Among them are DNA minor groove binders like Calicheamicins, Duocarmycins, and PBDs as well as topoisomerase inhibitors like Camptothecins and Daunorubicins/Doxorubicins, which damage DNA. Tubulin inhibitors include auristatins and maytansinoids. There are numerous conventional cytotoxic agents with comparable mechanisms of killing cancer cells that can also be used in the development of ADCs in addition to the listed cytotoxins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V75891 | DC10SMe | 2649727-40-0 | DC10SMe is a DNA alkylating agent that may be utilized to prepare active antibody conjugate molecules (ADC). |
|
V54473 | Diacetyl Agrochelin | 247115-75-9 | Diacetyl Agrochelin is an acetyl analogue of Agrochelin, which is produced by fermentation of marine Agrobacterium species. |
|
V51221 | Dideoxy-amanitin | 58255-46-2 | α-Amanitin derivative; ADC cytotoxin |
|
V53381 | DM3 (Maytansinoid DM3) | 796073-54-6 | DM3 (Maytansinoid DM3) is a maytansine analog with a disulfide bond or thiol group, an inhibitor (blocker/antagonist) of tubulin, and a cytotoxic part of ADCs (antibody-drug conjugates). |
|
V54468 | DM3-SMe | 796073-70-6 | DM3-SMe is a maytansine analogue, a tubulin inhibitor, and the cytotoxic part of an antibody-drug-conjugate/ADC (ADCs), which can be inhibited through disulfide bonds or stable thioethers. |
|
V53022 | DM4-SMe | 796073-68-2 | DM4-SMe is a metabolite of antibody-maytansine conjugate (AMC), a tubulin inhibitor, and a cytotoxic part of antibody-drug-conjugates/ADCss (ADCs). |
|
V51212 | DMEA-PNU-159682 | 1799421-48-9 | cytotoxin for ADCs |
|
V51213 | DMEA-PNU-159682 dichloroacetate | 1799421-49-0 | cytotoxin for ADCs |
|
V54463 | Duocarmycin Analog | 372954-15-9 | Duocarmycin Analog is an analogue of Duocarmycin, which could be utilized as a DNA alkylating agent (DNA alkylator) and the toxin part of an antibody-drug-conjugate/ADC (ADC cytotoxin). |
|
V79223 | Duocarmycin DM | Duocarmycin DM is a DNA minor-groove alkylator and an antibody active molecule conjugate (ADCs) toxin. | |
|
V52966 | Duostatin 5 | 2124210-34-8 | Duostatin 5 is a cytotoxin (cytotoxin) designed based on Aplysia toxin. |
|
V77054 | Dxd-d5 (Exatecan-d5 derivative for ADC) | Dxd-d5 is the deuterium labelled form of Dxd. | |
|
V76102 | Eg5-IN-2 | 1629735-05-2 | Eg5-IN-2 (Compound Scaffold B (4)) is an Eg5 inhibitor (IC50= < 0.5 nM). |
|
V77028 | Exatecan analog 36 | Exatecan analog 36 is a homologue of Exatecan. | |
|
V52990 | Exatecan Intermediate 1 (Exatecan Intermediate) | 110351-94-5 | Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan. |
|
V53196 | Exatecan Intermediate 2 | 182182-31-6 | Exatecan Intermediate 2 (compound B) is an intermediate of Exatecan (DX-8951). |
|
V77027 | Exatecan Intermediate 2 hydrochloride | Exatecan Intermediate 2 HCl (compound B) is an intermediate of Exatecan (DX-8951). | |
|
V54466 | Exatecan mesylate dihydrate (DX-8951 mesylate dihydrate) | 197720-53-9 | Exatecan (DX-8951) mesylate dihydrate is a DNA topoisomerase I (Top I) inhibitor (antagonist) with IC50 of 2.2 μM (0.975 μg/mL) and may be utilized in cancer research. |
|
V54482 | Exatecan-methylacetamide-OH | 2594423-51-3 | Exatecan-methylacetamide-OH (compound 6) is an Exatecan analogue with anti-cancer effects. |
|
V53395 | Fmoc-MMAE | 474645-26-6 | Fmoc-MMAE is a protecting group conjugated to MMAE. |
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