HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V31449 | SS-208 | 2245942-72-5 | SS-208 is a selective HDAC6 inhibitor (antagonist) with IC50 of 12 nM. |
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V8743 | Suprastat | 90093-40-6 | Suprastat is a novel, potent and selective HDAC6 (Histone Deacetylase 6) inhibitor with the ability to potentiate immunotherapy in melanoma. |
|
V4130 | Tinostamustine | 1236199-60-2 | Tinostamustine (also known as EDO-S101; EDO-S 101;Minomustine)is a novel, potent, fisrt-in-class alkylating agent and pan histone-deacetylase (HDAC)inhibitor with anticancer activity. |
|
V55226 | TNG260 | 2935964-98-8 | TNG260 is a CoREST selective deacetylase (CoreDAC) inhibitor. |
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V35169 | Triciferol | 957214-00-5 | Triciferol is a multi-ligand with combined VDR agonist and HDAC antagonist effects. |
|
V2404 | Tubastatin A TFA | 1239262-52-2 | Tubastatin A (TubA, AG-CR13900)TFA, the trifluoroacetic acid salt of TubA, is an inhibitor of HDAC6 with anticancer and anti-inflammatory activity. |
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V53101 | TYA-018 | 2653254-31-8 | TYA-018 is an orally bioactive and selective HDAC6 inhibitor. |
|
V55237 | XP5 | 2760511-91-7 | XP5 is a potent, orally bioactive HDAC6 inhibitor (antagonist) with IC50 of 31 nM. |
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