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    Suprastat
    Suprastat

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V8743
    CAS #: 90093-40-6Purity ≥98%

    Description: Suprastat is a novel, potent and selective HDAC6 (Histone Deacetylase 6) inhibitor with the ability to potentiate immunotherapy in melanoma. In vitro characterization of Suprastat demonstrates subnanomolar HDAC6 inhibitory potency and a hundred- to a thousand-fold HDAC6 selectivity over the other HDAC isoforms. In vivo studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances anti-tumor immune response, mediated by a decrease of pro-tumoral M2 macrophages and increased infiltration of anti-tumor CD8+ effector and memory T-cells.

    References: J. Med. Chem., Just Accepted Manuscript • DOI: 10.1021/acs.jmedchem.0c00567 • Publication Date (Web): 20 Aug 2020


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    Molecular Formula: C20H26N4O4
    Exact Mass: 386.1954
    Molecular Weight: 386.452

    Chemical Name: 4-((3-(4-(aminomethyl)phenyl)-1-(4-hydroxybutyl)ureido)methyl)-N-hydroxybenzamide


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