HDAC (Histone Deacetylases) are a group of enzymes that allow histones to more tightly wrap the DNA by removing acetyl groups (O=C-CH3) from -N-acetyl lysine amino acids. This is significant because DNA is wrapped around histones and that acetylation and de-acetylation control how DNA is expressed. In contrast to histone acetyltransferase, it acts differently. Since non-histone proteins are also among their targets, HDAC proteins are now also referred to as lysine deacetylases (KDAC) in order to better reflect their mode of action. The histone deacetylases are members of the ancient protein superfamily known as the histone deacetylase superfamily, along with the acetylpolyamine amidohydrolases and the acetoin utilization proteins.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V52000 | HDAC-IN-32 | 2766688-17-7 | HDAC-IN-32 is a potent HDAC inhibitor (antagonist) with IC50 of 5.2, 11 and 28 nM for HDAC1, HDAC2 and HDAC6 respectively. |
|
V51999 | HDAC-IN-33 | 2766688-19-9 | HDAC-IN-33 is a potent HDAC inhibitor (antagonist) with IC50s of 24, 46 and 47 nM for HDAC1, HDAC2 and HDAC6 respectively. |
|
V51997 | HDAC-IN-52 | 2075787-77-6 | HDAC-IN-52 is a pyridine-containing HDAC inhibitor (antagonist) with IC50s of 0.189, 0.227, 0.440 and 0.446 μM for inhibiting HDAC1, HDAC2, HDAC3 and HDAC10 respectively. |
|
V51996 | HDAC-IN-56 | 2814571-89-4 | HDAC-IN-56 ((S)-17b) is an orally bioactive class I histone deacetylase HDAC inhibitor (antagonist) with IC50s of 56.0±6.0 and 90.0 for HDAC1, HDAC2, HDAC3 and HDAC4-11, respectively. |
|
V55233 | HDAC-IN-58 | 2071224-39-8 | HDAC-IN-58 is an HDAC inhibitor. |
|
V29452 | HDAC-IN-7 | 743420-02-2 | HDAC-IN-7 is a Chidamide impurity. |
|
V55238 | HDAC/BET-IN-1 | 2757573-68-3 | HDAC/BET-IN-1 displays submicromolar inhibitory effect against HDAC1 and 6 (IC50 = 0.163 μM and 0.067 μM) and BRD4 (Ki = 0.076 μM), and has potent antileukemic activity. |
|
V75846 | HDAC1-IN-3 | 2482998-35-4 | HDAC1-IN-3 is a potent Pf HDAC1 inhibitor. |
|
V55228 | HDAC1/2-IN-3 | 2121516-17-2 | HDAC1/2-IN-3 is an inhibitor (blocker/antagonist) of HDAC1 and HDAC2 with IC50s of 0-5 and 5-10 nM, respectively. |
|
V75841 | HDAC2-IN-1 | 2919691-32-8 | HDAC2-IN-1 (Compound 17) is a brain-barrier-passing, orally bioactive, competitive HDAC2 inhibitor (antagonist) with IC50 of 0.5 μM. |
|
V52002 | HDAC6 degrader-3 | 2785404-83-1 | HDAC6 degrader-3 is a potent and specific HDAC6 degrader via ternary complex formation and the ubiquitin-proteasome pathway with IC50 of 19.4 nM. |
|
V75835 | HDAC6-IN-12 | 2803866-44-4 | HDAC6-IN-12 (compound GZ) is a potent HDAC6 inhibitor. |
|
V75843 | HDAC6-IN-13 | 2837128-41-1 | HDAC6-IN-13 (Compound 35m) is a specific, orally bioactive HDAC6 inhibitor (antagonist) with IC50 of 0.019 μM. |
|
V75836 | HDAC6-IN-21 | 2920929-76-4 | HDAC6-IN-21 (compound 13) is an irreversible inhibitor of histonedeacetylase 6(HDAC6). |
|
V75833 | HDAC6-IN-26 | 2991427-19-9 | HDAC6-IN-26 (compound 23) is a potent inhibitor of HDAC6. |
|
V75837 | HDAC6-IN-8 | 2796282-49-8 | A variety of compounds were designed and synthesized by modifying the Cap group. |
|
V75848 | HDAC6-IN-9 | 2796282-58-9 | HDAC6-IN-9 (compound 12c) is a potent and specific HDAC6 inhibitor (antagonist) with IC50s of 11.8, 15.2, 4.2, 139.6, and 21.3 nM for HDAC1, HDAC3, HDAC6, HDAC8, and HDAC10 respectively. |
|
V75844 | HDAC8-IN-2 | 2824131-20-4 | HDAC8-IN-2 (compound 5o) is a potent HDAC8 inhibitor (antagonist) with IC50s of 0.27 and 0.32 μM for smHDAC8 (Schistosoma mansoni histone deacetylase 8) and hHDAC8, respectively. |
|
V52001 | HDAC8-IN-4 | 1600528-05-9 | HDAC8-IN-4 is a selective inhibitor of HDAC8. |
|
V75832 | HFY-4A | 2094810-82-7 | HFY-4A is an HDAC inhibitor. |
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