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| 250mg |
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Purity: ≥98%
FAAH-IN-2 is a novel and potent FAAH (fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. It is also named as O-Desmorpholinopropyl Gefitinib and is a metabolite of gefitinib, which is an EGFR inhibitor. FAAHs (also known as EC 3.5.1.99, oleamide hydrolase, anandamide amidohydrolase) are a family of enzymes that belong to serine hydrolases. In humans, the family is represented by FAAH 1 and 2. It was first shown to break down anandamide in 1993. In humans, it is encoded by the gene FAAH. FAAH-IN-2 has the chemical name of 4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol; 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol; FAAH-IN-2; O-Desmorpholinopropyl Gefitinib; JLVTVCRXFMLUIF-UHFFFAOYSA-N.
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| References |
WO/2008/100977A2
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| Molecular Formula |
C₁₅H₁₁CLFN₃O₂
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| Molecular Weight |
319.72
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| CAS # |
184475-71-6
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| SMILES |
COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)O
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| InChi Key |
JLVTVCRXFMLUIF-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C15H11ClFN3O2/c1-22-14-6-12-9(5-13(14)21)15(19-7-18-12)20-8-2-3-11(17)10(16)4-8/h2-7,21H,1H3,(H,18,19,20)
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| Chemical Name |
4-(3-Chloro-4-fluorophenylamino)-7-methoxyquinazolin-6-ol; 4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-ol
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| Synonyms |
FAAH-IN-2; O-Desmorpholinopropyl Gefitinib; JLVTVCRXFMLUIF-UHFFFAOYSA-N
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.08 mg/mL (6.51 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1277 mL | 15.6387 mL | 31.2774 mL | |
| 5 mM | 0.6255 mL | 3.1277 mL | 6.2555 mL | |
| 10 mM | 0.3128 mL | 1.5639 mL | 3.1277 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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