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25mg | ||
50mg | ||
100mg | ||
Other Sizes |
Purity: ≥98%
This product has been discontinued from InvivoChem. UM729 (also known as UM-729; UM 729; C-07; C 07; C07) is an enhancer of aryl hydrocarbon receptor (AhR) antagonists. UM-729 enhances the self-renewal of human hematopoietic stem cells in vitro. UM729 has been found to be a new pyrimidoindole and have an additive efficacy with AhR antagonists in preventing differentiation in most AML specimen. In addition, UM729 has been reported to expand mormal HSPCs in a AhR-independent fashion.
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ln Vivo |
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Animal Protocol |
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References |
Nat Methods.2014Apr;11(4):436-42.
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Molecular Formula |
C20H25N5O2
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Molecular Weight |
367.44
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CAS # |
1448723-60-1
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SMILES |
O=C(OC)C1=CC=C(C2=C(NCCCN3CCCCC3)N=CN=C2N4)C4=C1
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.7215 mL | 13.6077 mL | 27.2153 mL | |
5 mM | 0.5443 mL | 2.7215 mL | 5.4431 mL | |
10 mM | 0.2722 mL | 1.3608 mL | 2.7215 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.