Phosphodiesterase (PDE) is any enzyme that breaks a phosphodiester bond.When phosphodiesterase is mentioned, it usually refers to cyclic nucleotide phosphodiesterases, which are discussed below and have significant clinical implications. There are numerous other families of phosphodiesterases, however, including the phospholipases C and D, autotaxin, sphingomyelin phosphodiesterase, DNases, RNases, and restriction endonucleases, in addition to a large number of less well-studied small-molecule phosphodiesterases.A group of enzymes known as cyclic nucleotide phosphodiesterases breaks down the phosphodiester bond in the second messenger molecules cAMP and cGMP. Within subcellular domains, they control the cyclic nucleotide signaling's amplitude, duration, and localization. Therefore, PDEs play a crucial role in controlling the signal transduction process that these second messenger molecules mediate.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V110770 | STF-1623 | 2298391-60-1 | STF-1623 is a potent ENPP1 inhibitor with an IC50 value of 0.6 nM. |
|
V96798 | T-0156 free base | 324572-92-1 | T-0156 free base is a potent and selective inhibitor of phosphodiesterase type 5 (PDE5). |
|
V118498 | T-1032 | 212500-03-3 | T-1032 is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. |
|
V118704 | T-1032 free base | 212500-02-2 | T-1032 free base is a selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 1.0 nM. |
|
V72065 | Tadalafil-d3 (IC-351-d3) | 960226-55-5 | Tadalafil-d3 is the deuterium labelled form of Nortadalafil. |
|
V91072 | Talaroterphenyl A | Talaroterphenyl A (compound 1) is a p-terphenyl derivative present in the mangrove sediment-derived fungus Talaromyces sp. | |
|
V118643 | TDP1-IN-4 | TDP1-IN-4 (compound 33) is a tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitor with an IC50 value of 0.90 μM. | |
|
V72044 | Theodrenaline hydrochloride ((±)-Theodrenaline hydrochloride) | 2572-61-4 | Theodrenaline HCl is a cardiotonic agent and is often mixed with Cafedrine in proportion to form Akrinor, which has a blood pressure lowering effect. |
|
V72026 | Thioquinapiperifil dihydrochloride (KF31327) | 204077-66-7 | Thioquinapiperifil di-HCl (KF31327) is a specific, noncompetitive (IC50 of 0.074 nM) inhibitor of phosphodiesterase (PDE-5) for studies of sexual maturation. |
|
V16347 | THPP-1 | 1257051-63-0 | THPP-1 is a novel, potent and orally bioavailable PDE10A (phosphodiesterase 10A) inhibitor withKi values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. |
|
V72016 | TMX-4100 | 2367619-63-2 | TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. |
|
V72085 | Toddacumalone | 139750-79-1 | Toddacoumalone is a natural phosphodiesterase 4 (PDE4) inhibitor (antagonist) with moderate potency and imperfect active molecule-like properties. |
|
V92282 | Tolafentrine | 139308-65-9 | Tolafentrine is a dual-selective phosphodiesterase 3/4 (PDE3/4) inhibitor that has been shown to have significant acute and chronic effects in a unilateral bisacetamide-induced rat model of pulmonary hypertension. |
|
V87670 | Torbafylline | 105102-21-4 | Torbafylline is a PDE inhibitor. |
|
V72034 | TPN729 | 936951-20-1 | TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor (antagonist) with IC50 of 2.28 nM. |
|
V72036 | TPN729MA (TPN729 maleate) | 1422955-52-9 | TPN729MA (TPN729 maleate) is a selective phosphodiesterase type 5 (PDE5) inhibitor (antagonist) with IC50 of 2.28 nM. |
|
V72011 | Trequinsin hydrochloride (HL 725) | 78416-81-6 | Trequinsin HCl (HL 725) is a potent inhibitor of platelet CAMP phosphodiesterase (PDE) with IC50 of 0.25 nM. |
|
V72045 | Udenafil-d7 (Udenafil d7) | 1175992-76-3 | Udenafil-d7 is the deuterium labelled form of Udenafil. |
|
V110908 | UK 343664 | 215297-27-1 | UK Medicines Code 343664 is a potent, orally effective selective PDE5 inhibitor. |
|
V116280 | UK-371800 | 247582-13-4 | UK-371800 is a highly selective PDE5 inhibitor (IC50 = 4.2 nM). |
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