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Phosphatase

Phosphatase

Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.

Phosphatase related products

Structure Cat No. Product Name CAS No. Product Description
(+)-Crinatusin A1 V121174 (+)-Crinatusin A1 (+)-Crinatusin A1 is a chalcone-monoterpene heterocomplex that can be isolated from Cleistocalyx operculatus.
(-)-4-溴四咪唑 草酸盐 V1929 (-)-p-Bromotetramisole Oxalate 62284-79-1 p-Bromotetramisole Oxalate (also known as L-p-Bromotetramisole Oxalate)is a potent,cell-permeable and non-specific alkaline phosphatase inhibitor.
(1S,2S,3R)-DT-061 V32191 (1S,2S,3R)-DT-061 1809427-20-0 1S,2S,3R)-DT-061 is an isomer/enantiomer of DT-061 (DT061), which is a novel and orally bioavailable activator of protein phosphatase 2A (PP2A) and may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
(24E)-3,4-Secocucubita-4,24-diene-3,26,29-trioic acid V73343 (24E)-3,4-Secocucubita-4,24-diene-3,26,29-trioic acid 329975-47-5 (24E)-3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid is a potent PTP1B inhibitor (antagonist) with IC50=0.4 μM.
(3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane V73349 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane 1180504-64-6 (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane is a homoisoflavone.
(4-Phenylphenoxy)phosphonic acid V121601 (4-Phenylphenoxy)phosphonic acid 46817-52-1 (4-Phenylphenoxy)phosphonic acid is a protein tyrosine phosphatase (PTP) inhibitor (KM: 86 μM).
(E/Z)-3PO V121795 (E/Z)-3PO 13309-08-5 (E/Z)-3PO is a potent PFKFB3 inhibitor.
(E/Z)-Icerguastat acetate V87661 (E/Z)-Icerguastat acetate 469866-31-7 (E/Z)-Icerguastat ((E/Z)-Sephin1) acetate is a selective inhibitor of phosphatase regulatory subunit (PPP1R15A (R15A)).
(E/Z)-Raphin1 V89794 (E/Z)-Raphin1 94023-67-3 (E/Z)-Raphin1 is an inhibitor of PPP1R15B, a regulatory subunit of protein phosphatase 1.
(GalNAc)3-CPT V119111 (GalNAc)3-CPT (GalNAc)3-CPT is a glycoconjugate prodrug that targets the desialylate glycoprotein receptor (ASGR) overexpressed on hepatocytes.
(R)-Azasetron besylate (SENS-401) V73318 (R)-Azasetron besylate (SENS-401) 2025360-91-0 (R)-Azasetron besylate (SENS-401) is an orally bioactive calcineurin inhibitor.
(R)-GSK 2830371 V103575 (R)-GSK 2830371 2743427-27-0 (R)-GSK 2830371 is the R-enantiomer of GSK 2830371.
(Rac)-RK-682 V73321 (Rac)-RK-682 154639-24-4 (Rac)-RK-682 is the racemate of RK-682 and is an inhibitor (blocker/antagonist) of protein tyrosine phosphatases (PTPases).
(±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane V102675 (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane 257641-01-3 (±)-trans-1,2-bis(2-mercaptoacetamide)cyclohexane is a dithiol small molecule catalyst with a low thiol pKa value (8.3) and a high reduction potential (-0.24 V), which can mimic the activity of PDI.
1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine V122688 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine 61599-23-3 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine is a phosphatidylethanolamine that enhances the activity of PP2A and PTP1B in malignant pleural mesothelioma cells.
1-Naphthyl phosphate potassium salt V73312 1-Naphthyl phosphate potassium salt 100929-85-9 1-Naphthyl phosphate potassium salt is a non-specific phosphatase inhibitor.
11R-CaN-AID V85688 11R-CaN-AID 650603-03-5
12-NBD Stearate V123129 12-NBD Stearate 117056-67-4 12-NBD Stearate is a fluorescent fatty acid analog.
2-Bromo-4'-hydroxyacetophenone V73304 2-Bromo-4'-hydroxyacetophenone 2491-38-5 2-Bromo-4'-hydroxyacetophenone is a potent inhibitor of PTP1B with Ki of 42 μM.
2-Hydroxymethyl-3-hydroxyanthraquinone V73333 2-Hydroxymethyl-3-hydroxyanthraquinone 68243-30-1 2-Hydroxymethyl-3-hydroxyanthraquinone is an anti-osteoporotic compound that can inhibit osteoclast tartrate-resistant acid phosphatase (TRAP) activity.
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