Phosphatases are enzymes that strip a protein of its phosphate group. PTPs (protein tyrosine phosphatases) are a large family of cytoplasmic and transmembrane enzymes. PTPs are crucial in maintaining the integrity of cell-cell and cell-matrix contacts as well as controlling the proliferative activity of cells. PTP1B, a non-receptor PTP, is frequently found in the endoplasmic reticulum and in vesicles that are close to the plasma membrane.PTP1B has been a popular therapeutic target for the management of type 2 diabetes mellitus and obesity due to its important role as a negative regulator of leptin receptor pathways. Animal cell cytoplasm contains four major serine/threonine-specific protein phosphatase catalytic subunits. While PP2C seems to be different from the other two, PP1, PP2A, and PP2B, all three of these enzymes are members of the same gene family. A diverse group of enzymes known as alkaline phosphatases is found in abundance in mammalian cells. Following the general equation, acid phosphatase enzymes catalyze the hydrolysis of phosphate monoesters.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V73309 | Tegeprotafib (PTPN2/1-IN-1) | 2407610-46-0 | Tegeprotafib (PTPN2/1-IN-1) is an orally bioactive PTPN1 and PTPN2 inhibitor (antagonist) with IC50s of 4.4 nM and 1-10 nM for PTPN2 and PTP1B, respectively. |
|
V101880 | TNAP-IN-1 | 496014-13-2 | TNAP-IN-1 (Compound 1) is a selective tissue nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 0.19 μM. |
|
V73299 | TRC-766 | 1810734-44-1 | TRC-766 is a negative control (NC) for RTC-5 (TRC-382). |
|
V69424 | Tyrphostin 8 | 3785-90-8 | Tyrphostin 8 is a tyrosine kinase that can inhibit EGFR kinase with IC50 of 560 μM. |
|
V73305 | Uralenol | 139163-15-8 | Uralenol is a natural PTP1B inhibitor from Broussonetia papyrifera (IC50=21.5 μM). |
|
V73322 | Uralsaponin D | 1262489-44-0 | Uralsaponin D is a saponin extracted from Glycyrrhiza uralensis. |
|
V106182 | WVSAV | WVSAV is a PDZ2 domain (tyrosine phosphatase) ligand with Kd of 111 μM. | |
|
V89134 | λ Protein phosphatase | 401941-75-1 | λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. |
|
V3607 | Tacrolimus Monohydrate | 109581-93-3 | Tacrolimus (formerly also known as FK-506), amacrocyclic lactone isolated from the culture broth of a strain of Streptomyces tsukubaensis, is an immunosuppressive agent used mainly after allogeneic organ transplant to reduce the activity of the patients immune system and to lower the risk of organ rejection. |
|
V1983 | Pimecrolimus (ASM 981) | 137071-32-0 | Pimecrolimus (formerly known as ASM-981; SDZ-ASM981) is an ascomycin analog which acts asan immunomodulating agent and is used in the treatment of atopic dermatitis. |
|
V0182 | Sodium orthovanadate | 13721-39-6 | Sodium orthovanadate, an inorganic compound with chemical formula ofNa3VO4, is a potent inhibitor for several enzymes such as protein tyrosine phosphatases (PTPs), alkaline phosphatase (ALP), and ATPase. |
|
V31026 | Silydianin | 29782-68-1 | Silydianin is the active component of milk thistle and has anti-collagenase and anti-elastase activity. |
|
V29922 | Licoflavone A | 61153-77-3 | Licoflavone A is a flavonoid obtained from licorice root and inhibits the activity of tyrosine phosphatase 1B (PTP1B) with IC50 of 54.5 μM. |
|
V22435 | Idoxuridine | 54-42-2 | Idoxuridine (IdUrd; 5-Iodo-2′-deoxyuridine; 5-IUdR) is a potent anti-herpesvirus antiviral and anticancer drug. |
|
V13995 | Rosiptor | 782487-28-9 | Rosiptor (AQX-1125; AQX1125; AQX 1125) is an orally bioavailable and selective activator of the phosphatase SHIP1 (SH2 domain-containing inositol-5′-phosphatase 1) with potential anti-inflammatory activities. |
|
V4335 | SURAMIN SODIUM | 129-46-4 | Suramin sodium salt, a polysulfonated naphthylurea analog, is a novel and potentDNA topoisomerase IIinhibitor with anIC50of 5 μM. |
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