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    Pitavastatin Calcium (NK-104)
    Pitavastatin Calcium (NK-104)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1859
    CAS #: 147526-32-7 Purity ≥98%

    Description: Pitavastatin calcium (also called NK-104 Calcium) is a novel and potent drug of the statin class. Pitavastatin Calcium acts as a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase), resulting in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.

    References: Cardiol Rev. 2010 Sep-Oct;18(5):264-7; J Clin Invest. 2001 Jun;107(11):1423-32.

    Related CAS #: 147526-32-7 (calcium); 586966-54-3 (tert-Buthyl Pitavastatin); 147511-69-1 (free acid); 141750-63-2 (lactone); 1159588-21-2 [(Z)-Pitavastatin cacium]; 254452-92-1 [(3S,5S)-Pitavastatin cacium]; 254452-88-5 [(3S,5R)-Pitavastatin cacium]; 2070009-71-9 (Pitavastatin D4); 141750-63-2 (Pitavastatin lactone); 

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    Molecular Weight (MW)880.98 
    FormulaC50H46CaF2N2O8 
    CAS No.147526-32-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 51 mg/mL (57.9 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: calcium (E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoate

    InChi Key: RHGYHLPFVJEAOC-WUVPNHNWSA-L

    InChi Code: InChI=1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;

    SMILES Code: C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]

    SynonymsNK-104 Calcium; Livalo; NK104; Pitavastatin hemicalcium; Nisvastatin; NK 104; NK-104; P 872441; P-872441 


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    In Vitro

    In vitro activity: Pitavastatin significantly reduces both intracellular levels and synthesis of cholesterol esters. Pitavastatin is found to enhance LDL-receptor expression in vitro, as well as the amount of LDL binding to the LDL-receptor. Pitavastatin also exhibits more potent induction of LDL receptor mRNA expression compared with simvastatin and atorvastatin. Pitavastatin has many pleiotropic effects in vitro and in vivo, including deterring progression of atherosclerosis via inhibition of thromboxane synthesis, inhibition of migration/proliferation of vascular smooth muscle cells induced by angiotensin II, and stabilization of atherosclerotic plaque. Pitavastatin is able to activate PPARα and induce HDL apoA-I through inducing inhibition of the Rho-signaling pathway. Pitavastatin (1 μM) treatment for 48 h is able to enhances bone morphogenetic protein-2 BMP-2 (2.5-fold) and osteocalcin (10-fold) expression by inhibition of Rho-associated kinase in human osteoblasts.

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    References

    Cardiol Rev. 2010 Sep-Oct;18(5):264-7; J Clin Invest. 2001 Jun;107(11):1423-32. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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