HIFs (Hypoxia-inducible factors) are transcription factors that react to variations in the amount of oxygen available to cells, more specifically, to reductions in oxygen, or hypoxia. The effects of hypoxia, a condition of low oxygen concentration, on the cell are mediated by the HIF signaling cascade. Oftentimes, hypoxia prevents cells from differentiating. However, hypoxia encourages the growth of blood vessels and is crucial for the development of a vascular system in both cancer tumors and embryos.Additionally, the hypoxia in wounds encourages keratinocyte migration and epithelium repair. HIFs are essential to development in general. HIF-1 gene deletion in mammals causes perinatal death. It has been demonstrated that HIF-1 is essential for chondrocyte survival and enables the cells to adapt to low oxygen environments in the growth plates of bones. Human metabolism is controlled in large part by HIF. A number of medications that function as selective HIF prolyl hydroxylase inhibitors have recently been created.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51614 | HIF-1/2α-IN-1 | 2827693-99-0 | HIF-1/2α-IN-1 is a HIF-2α receptor that is transcriptionally active. |
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V76933 | HIF-1α-IN-2 hydrochloride | HIF-1α-IN-2 HCl is a potent HIF-1α inhibitor (antagonist) with anticancer effects, with IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. | |
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V51616 | HIF-1α-IN-4 | 2826221-23-0 | HIF-1α-IN-4 is a form of HIF-1α with IC50 of 24 nM in HEK293T cells. |
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V51613 | HIF-1α-IN-5 | 2826221-10-5 | HIF-1α-IN-5 is a HIF-1α reagent with IC50 of 24 nM in HEK293T cells. |
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V79721 | HIF-1α-IN-6 | HIF-1α-IN-6 (compound 3s) is a HIF-1α inhibitor (antagonist) with IC50s of 0.6 and 53.3 nM observed in MiaPaCa-2 and MDA-MB-231 cells. | |
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V51618 | HIF-2α agonist 2 | 2750141-15-0 | HIF-2α Agonist 2 (Compound 10) is a HIF-2α agonist/activator with EC50 of 1.68 μM at a dose of 20 μM. |
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V51617 | HIF-2α-IN-8 | 2734922-78-0 | HIF-2α-IN-8 is a potent HIF2α activator with epidermal activity. |
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V73838 | HIF-2α-IN-9 | 2648334-36-3 | HIF-2α-IN-9 (compound 35r) is an inhibitor (blocker/antagonist) of HIF-2α. |
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V51619 | HIF-PHD-IN-1 | 1567657-46-8 | HIF-PHD-IN-1 is a dye for the hypoxia-inducible factor tyrosine kinase foam reflux platforming enzyme domain (HIF-PHD) with apoptosis pathway activity. |
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V51620 | HIF-PHD-IN-3 | 794582-71-1 | HIF-PHD-IN-3 (compound 4) is an effective hiPSC-CM cardioprotective scaffold. |
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V79795 | HIV-IN-7 | Axl-IN-16 (Compound 4) is an Axl inhibitor. | |
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V0252 | Hydralazine HCl (Apresoline, Adrolazine , Apresrex) | 304-20-1 | Hydralazine HCl (Apresoline, Adrolazine , Apresrex), thehydrochloride salt of hydralazine,is a potent and direct-acting smooth muscle relaxant and vasodilatorused for the treatment of hypertension. |
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V51615 | Imdatifan (HIF-2α-IN-7) | 2511247-29-1 | Imdatifan (HIF-2α-IN-7) is a hypoxia-inducible factor 2α (HIF-2α) dye. |
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V51636 | IOX2 sodium | 2377239-85-3 | IOX2 Sodium is an upper left pulsed styrene-dissolving enzyme-2 (PHD2) couple with IC50 of 22 nM. |
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V51629 | Izilendustat | 1303512-02-8 | Izilendustat is a potent prolyl hydroxylase (prolyl hydroxylase) that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2). |
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V51628 | Izilendustat hydrochloride | 1303513-80-5 | Izilendustat (HCl) is a potent prolyl phosphatidylase (prolyl hydroxylase) that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2 ). |
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V3444 | JNJ-42041935 | 1193383-09-3 | JNJ-42041935 is a novel, potent, competitive, reversible, and selective inhibitor of prolyl hydroxylasePHDwithpKivalues of 7.91±0.04, 7.29 ±0.05, and 7.65±0.09 for PHD1, PHD2, and PHD3, respectively. |
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V51631 | KG-548 | 175205-09-1 | KG-548 is an ARNT/TACC3 interferon and HIF-1α. |
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V2781 | LW6 | 934593-90-5 | LW6 is a hypoxia-inducible factor 1 (HIF) inhibitor which potently inhibits HIF-1α accumulation by degrading HIF-1α without affecting the HIF-1a mRNA levels during hypoxia. |
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V4021 | ML228 | 1357171-62-0 | ML228 (ML-228; CID-46742353) is an activator of the Hypoxia Inducible Factor (HIF) which potently activate HIF in vitro as well as its downstream target VEGF. |
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