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    Hydralazine HCl (Apresoline, Adrolazine , Apresrex)
    Hydralazine HCl (Apresoline, Adrolazine , Apresrex)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0252
    CAS #: 304-20-1Purity ≥98%

    Description: Hydralazine HCl (Apresoline, Adrolazine , Apresrex), the hydrochloride salt of hydralazine, is a potent and direct-acting smooth muscle relaxant and vasodilator used for the treatment of hypertension. It acts as a vasodilator primarily in arteries and arterioles. 

    References: Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6317-22; J Pharmacol Exp Ther. 2004 Sep;310(3):1003-10.

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    Molecular Weight (MW)196.64 
    FormulaC8H8N4.HCl 
    CAS No.304-20-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: phthalazin-1-ylhydrazine; hydrochloride

    InChi Key: ZUXNZUWOTSUBMN-UHFFFAOYSA-N

    InChi Code: InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H

    SMILES Code: C1=CC=C2C(=C1)C=NN=C2NN.Cl

    Synonyms

    Hydralazine Hydrochloride; 1-Hydrazinophthalazine; Adrolazine , Apresrex; Apresoline; Hydralazine chloride; Aiselazine;  mono-Hydrochloride, Hydralazine; Nepresol


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    In Vitro

    In vitro activity: Hydralazine impairs up-regulation of RAG-2 gene expression and reduces secondary Ig gene rearrangements. Hydralazine subverts B lymphocyte tolerance to self and contributes to generation of pathogenic autoreactivity by disrupting receptor editing. Hydralazine directly scavenges free acrolein, decreasing intracellular acrolein availability and thereby suppressing macromolecular adduction. Hydralazine inhibits cross-linking if adding 30 min after commencing acrolein exposure but is ineffective if added after a 90-min delay. Hydralazine (0.1-10 mM) inhibits both extracellular and intracellular ROS production by inflammatory macrophages, by a ROS-scavenging mechanism probably affecting superoxide radical (O(2)(*-))-generation by xanthine oxidase (XO) and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase. Hydralazine (0.1-10 mM) significantly reduces NO(*) generation, and this effect is attributable to an inhibition of NOS-2 gene expression and protein synthesis. Hydralazine also effectively blocks COX-2 gene expression which perfectly correlated with a reduction of protein levels and PGE(2) synthesis.

    In VivoHydralazine affords strong, dose-dependent protection against the increases in plasma marker enzymes but not the hepatic glutathione depletion produced by allyl alcohol in mice.  
    Animal modelMice
    Formulation & DosageN/A
    References

    Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6317-22; J Pharmacol Exp Ther. 2004 Sep;310(3):1003-10. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Hydralazine HCl

    Hydralazine and a MEK inhibitor block Vκ–Jκ5 rearrangements after BcR stimulation. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6317-22.
     

    Hydralazine HCl

    Treatment of bone marrow cells from transgenic mice with hydralazine or a MEK inhibitor induces autoantibody production in syngeneic animals. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6317-22.


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