| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
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| 10mg |
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| 50mg |
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| Other Sizes |
| ln Vitro |
HK-2-IN-1 (compound 20) (50-1000 μM, 48 hours) showed cytotoxicity against HCT-116, HepG2, 4T1 and MCF7 cells, with IC50 values of 22.04 μM, 21.19 μM, 54.69 μM and 192.3 μM, respectively, and had no cytotoxic effect on healthy fibroblasts [1].
|
|---|---|
| ln Vivo |
HK-2-IN-1 (compound 20) (5 mg/kg, intraperitoneal injection, once daily for 4 weeks) inhibited tumor growth and metastasis in 4T1 tumor mice [1].
|
| Animal Protocol |
Animal/Disease Models:4T1 tumor cell xenograft BALB/c mouse model [1]
Doses: 5 mg/kg Route of Administration: Intraperitoneal injection, once daily for 4 weeks Experimental Results: Inhibited the growth and metastasis of 4T1 tumors; in 2 out of 4 mice treated with cyclophosphamide (CTX), the tumors almost completely regressed. Reduced tumor-infiltrating gMDSCs and increased the infiltration of CD8 T lymphocytes in the tumor. |
| References |
| Molecular Formula |
C23H16CL2FN5
|
|---|---|
| Molecular Weight |
452.31
|
| CAS # |
3114833-48-3
|
| Appearance |
White to off-white solid
|
| SMILES |
ClC(C=C1Cl)=CC=C1CN(C2=CC(F)=CC=C23)N=C3C4=NC(CC5=CC=CC=C5)=NN4
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: 本产品在运输和储存过程中需避光（避免光照）。 |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~110.54 mM; with sonication)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), Clear solution.
For example, if 1 mL of working solution is to be prepared, you canAdd 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of corn oil and mix well. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2109 mL | 11.0544 mL | 22.1087 mL | |
| 5 mM | 0.4422 mL | 2.2109 mL | 4.4217 mL | |
| 10 mM | 0.2211 mL | 1.1054 mL | 2.2109 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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