Size | Price | Stock | Qty |
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5mg |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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ln Vitro |
The modulation of arginine 7-amino-4-methylcoumarin (AMC) manpower (Arg-AMC), catalyzed by LTA4H, is inhibited by LTA4H-IN-1 (15 min) with an IC50 of 2 nM [1]. In the human whole blood assay (hWB), LTA4H-IN-1 (30 min) suppresses LTB4 production with an IC50 of 167 nM [1].
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ln Vivo |
LTA4H-IN-1 (0.3 mg/kg; one pass) reduced LTB4 release in mice by -43% as compared to vehicle [1].
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References |
[1]. Bollbuck B, et, al. Heteroaryl butanoic acid derivatives as leukotriene A4 hydrolase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2015092740A1.
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Molecular Formula |
C16H14CLFN6O3
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Molecular Weight |
392.7754
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Exact Mass |
392.08
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Elemental Analysis |
C, 48.93; H, 3.59; Cl, 9.03; F, 4.84; N, 21.40; O, 12.22
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CAS # |
1799681-85-8
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SMILES |
O=C(O)C[C@H](N)CN1N=C(C2=CC=C(OC3=NC=C(Cl)C=C3F)C=C2)N=N1
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InChi Key |
ZEGMEJVULDALSH-NSHDSACASA-N
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InChi Code |
InChI=1S/C16H14ClFN6O3/c17-10-5-13(18)16(20-7-10)27-12-3-1-9(2-4-12)15-21-23-24(22-15)8-11(19)6-14(25)26/h1-5,7,11H,6,8,19H2,(H,25,26)/t11-/m0/s1
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Chemical Name |
(S)-3-amino-4-(5-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenyl)-2H-tetrazol-2-yl)butanoic acid
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Synonyms |
LYS-006 LYS 006 LYS006
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~254.60 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.5460 mL | 12.7298 mL | 25.4595 mL | |
5 mM | 0.5092 mL | 2.5460 mL | 5.0919 mL | |
10 mM | 0.2546 mL | 1.2730 mL | 2.5460 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.