Acetyl-CoA Carboxylase

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Acetyl-CoA Carboxylase

The ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in the synthesis of fatty acids, is catalyzed by acetyl-CoA carboxylase. Acetyl-CoA carboxylase is a desirable target for the development of drugs to treat diabetes, cancer, and other diseases because of its critical roles in fatty acid metabolism.

Animals have two main ACC isoforms, ACC1 and ACC2, which are each encoded by a different gene and have different distributions in different tissues and cells. ACC, which is mediated by the related enzymes ACC1 and ACC2, catalyzes the ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA as the first committed step of fatty acid synthesis (FASyn). While ACC2 is attached to the mitochondrial outer membrane, where localized malonyl-CoA production inhibits carnitine palmitoyltransferase-1 (CPT-1) function to stop fatty acids from entering the mitochondria to undergo fatty acid oxidation (FAOxn), ACC1 encodes a cytoplasmic isoform that is thought to be the predominant isoform controlling FASyn.

Acetyl-CoA Carboxylase related products

Cat No.	Product Name	CAS No.	Product Description
V97305	(Rac)-Spirotetramat-enol	382608-09-5	(Rac)-Spirotetramat-enol (Compound 8) is a ligand for acetyl-CoA carboxylase and can be used to synthesize PROTAC ADC degraders.
V3018	TOFA (Olumacostat)	54857-86-2	TOFA (5‑tetradecyloxy‑2‑furoic acid), also known as RMI14514 and MDL14514, is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA).
V128071	ACC-IN-1	2270839-89-7	ACC-IN-1 is an allosteric inhibitor of acetyl-CoA carboxylase (ACC).
V99615	ACC1-IN-2	3027705-67-2	ACC1-IN-2 (Compound 16) is an inhibitor of ACC1 with IC50 of 7.3 nM.
V128070	ACC1/2-IN-3	2131091-32-0	ACC1/2-IN-3 is an inhibitor of ACC1 and ACC2, with IC50 values of 1-10 nM for both.
V128780	AMPK activator 16	2252336-04-0	AMPK activator 16 is an inhibitor of AMP-activated protein kinase (AMPK).
V128817	Andrimid	108868-95-7	Andrimid is a peptide antibiotic and an acetyl-CoA carboxylase inhibitor.
V112485	CKBA	1786406-66-3	CKBA is a derivative of AKBA and is an inhibitor of acetyl-CoA carboxylase 1 (ACC1), with an IC50 value of 5.02 μM.
V4530	CMS121	1353224-53-9	CMS-121 (CMS121) is a novel and potent fisetin-basedquinolonederivative acting as anorally active acetyl-CoA carboxylase 1 (ACC1) inhibitorwith anti-aging, neuroprotective, anti-inflammatory, antioxidative, and renoprotective activities.
V73884	CP-610431	591778-83-5	CP-610431 is a reversible, ATP-noncompetitive, isoenzyme-nonselective inhibitor of acetyl-CoA carboxylase (ACC).
V2852	CP640186 HCl	591778-70-0	CP-640186 HCl is a novel and potent inhibitor of mammalian ACCs (isozyme-nonselective acetyl-CoA carboxylase) with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; It hash improved metabolic stability in comparison to CP-610431, an analog of CP-640186.
V73881	Firsocostat (racemate)	2128714-16-7	Firsocostat (racemate) (ND-630 racemate) is the racemate (R/S-isomer) of Firsocostat.
V3778	Firsocostat (S enantiomer)	2128714-16-7	ND-630 S enantiomer, the S enantiomer of ND-630 (also known as GS-0976; NDI-010976; firsocostat), is a potent inhibitor of ACC (acetyl-CoA carboxylase).
V93087	Fluazifop	69335-91-7	Fluazifop is a selective herbicide that acts by inhibiting acetyl-CoA carboxylase.
V109680	Fluazifop-d3		Flupyrazosulfuron-d3 is a deuterated derivative of flupyrazosulfuron.
V73880	Fluazifop-P-butyl	79241-46-6	Fluazifop-P-butyl is an herbicide developed from arylphenoxypropionate and an acetyl-CoA carboxylase (ACCase) inhibitor.
V104777	Gigantetrocin	134955-48-9	Gigantetrocin is a biologically active annona acetyl-CoA from goniothalamus giganteus.
V73882	Haloxyfop	69806-34-4	Haloxyfop is an arylchlorooxyphenoxypropionic acid herbicide that is extensively used on weeds in broadleaf crops.
V118327	Insecticidal agent 26		Insecticide 26 (compound A11) is a spirocyclic insecticide that simultaneously inhibits acetyl-CoA carboxylase (ACC) and pyruvate carboxylase (PC) in pests.
V139708	Metamifop	256412-89-2	Metamifop is a post-emergence lipid synthesis inhibitor herbicide with an IC50 value of 41.1 nM against the carboxyltransferase (CT) domain of acetyl-CoA carboxylase (ACCase) in barnyard grass (Echinochloa crus-galli).