TLR

TLR

A group of proteins known as toll-like receptors (TLRs) are essential components of the innate immune system. They are single, membrane-spanning, non-catalytic receptors that recognize structurally conserved molecules derived from microbes and are typically expressed in sentinel cells like macrophages and dendritic cells. Once these microbes have gotten past physical barriers like the skin or mucosa of the gastrointestinal tract, TLRs recognize them and trigger immune cell responses.

TLR1 through TLR13 are among the TLRs, along with TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10, TLR11, TLR12, and TLR13. Toll-Like Receptors (TLRs) are involved in both the detection of endogenous danger signals and the early innate immune response to encroaching pathogens. TLRs are homologs of the Drosophila Toll protein, which was found to be crucial for defense against microbial infection. They are evolutionarily conserved receptors. TLRs identify pathogen-associated microbial patterns (PAMPs), which are only expressed by microbial pathogens and are highly conserved structural motifs.

TLR related products

Structure Cat No. Product Name CAS No. Product Description
V37647 TLR4-IN-C34 40592-88-9 TLR4-IN-C34 is an orally bioactive TLR4 inhibitor that improves systemic inflammation in models of endotoxemia and necrotizing enterocolitis.
V76410 TLR4-IN-C34-C2-amide-C6-OH TLR4-IN-C34-C2-amide-C6-OH is a linker containing the TLR4 inhibitor TLR4-IN-C34.
V74345 TLR4-IN-C34-C2-COOH 1159408-54-4 TLR4-IN-C34-C2-COOH is a linker containing the TLR4 inhibitor TLR4-IN-C34.
V74364 TLR4agonist-1 2374139-51-0 TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4) and induces MIP-1β production in RAW 264.7 and MM6 cells.
V81595 TLR4agonist-1TEA TLR4 agonist-1 (TEA) (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4) and induces MIP-1β production in RAW 264.7 and MM6 cells.
V51764 TLR7 agonist 11 2389988-36-5 TLR7 agonist 11 is an analogue of purine nucleoside.
V51762 TLR7 agonist 12 2389988-47-8 TLR7 agonist 12 (Example 20) is a TLR7 agonist and an analogue of purine nucleoside.
V74377 TLR7 agonist 14 2832199-45-6 TLR7 agonist 14 (compound 17b) is a potent TLR7 agonist/activator with EC50 of 59 nM.
V74368 TLR7 agonist 16 2832199-56-9 TLR7 agonist 16 (compound 16d) is a potent TLR7 agonist/activator with EC50 of 59 nM.
V85171 TLR7 agonist 17 2410517-32-5
V84751 TLR7 agonist 18
V84402 TLR7 agonist 19 2682008-42-8
V4750 TLR7 agonist 2 1642857-69-9 TLR7 agonist 2 is a novel, oral, potent and selective agonist of Toll-like Receptor 7(TLR7) with antiviral activity.
V51761 TLR7 agonist 5 2380231-67-2 TLR7 agonist 5 (compound IIb-11) is a potent TLR7 agonist/activator with EC50 of about 4 nM.
V51758 TLR7 agonist 6 2380231-86-5 TLR7 agonist 6 (compound IIb-19) is a potent TLR7 agonist/activator with EC50=1.0 nM.
V51759 TLR7 agonist 7 2380231-77-4 TLR7 agonist 7 (compound IIb-26) is a potent TLR7 agonist/activator with EC50 of about 4 nM.
V51760 TLR7 agonist 8 2380231-81-0 TLR7 agonist 8 (compound IIb-34) is a potent TLR7 agonist/activator with EC50 of about 4 nM.
V51757 TLR7 agonist 9 2389988-38-7 TLR7 agonist 9 (compound 10) is a TLR7 agonist that may be utilized in cancer and infection research.
V40861 TLR7/8 agonist 1 1258457-59-8 TLR7/8 agonist 1is an agonist of TLR7/8 that can be used as an adjuvant for skin treatment of virus-associated warts and basal cell carcinoma.
V51767 TLR7/8 agonist 4 2388520-33-8 TLR7/8 agonist 4 (compound 41) is a potent TLR7/8 agonist.
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