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STING

STING

The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.

STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.

STING related products

Structure Cat No. Product Name CAS No. Product Description
STING agonist-17 V74328 STING agonist-17 2816929-47-0 STING agonist-17 (compound 4a) is a potent STING agonist/activator with IC50 of 0.062 nM.
STING agonist-18 diTFA V101259 STING agonist-18 diTFA 2138299-69-9 STING agonist-18 diTFA (compound 1a) can be used to synthesize antibody-activated molecule conjugates (ADCs), such as trastuzumab conjugates.
STING agonist-21 V85372 STING agonist-21 2375419-35-3
STING agonist-22 V74313 STING agonist-22 2408723-12-4 STING agonist-22 (CF501) is a potent non-nucleotide STING agonist.
STING agonist-23 V51054 STING agonist-23 2361570-16-1 STING agonist-23 (CF502) is a novel non-nucleotide-based STING agonist.
STING agonist-24 V51055 STING agonist-24 2408722-91-6 STING agonist-24 (CF504) is a novel non-nucleotide-based STING agonist.
STING agonist-25 V51053 STING agonist-25 2408723-10-2 STING agonist-25 (CF505) is a novel non-nucleotide-based STING agonist.
STING agonist-26 V51057 STING agonist-26 2868261-48-5 STING agonist-26 (CF508) is a novel non-nucleotide-based STING agonist.
STING agonist-27 V74320 STING agonist-27 2868261-45-2 STING agonist-27 (CF509) is a non-nucleotide small molecule STING agonist.
STING agonist-28 V51056 STING agonist-28 2868261-50-9 STING agonist-28 (CF510) is a novel non-nucleotide-based STING agonist.
STING agonist-29 V74330 STING agonist-29 2868261-51-0 STING agonist-29 (CF511) is a non-nucleotide small molecule STING agonist.
STING agonist-3 trihydrochloride V76475 STING agonist-3 trihydrochloride STING agonist-3 tri HCl, found in patent WO2017175147A1 (Example 10), is a selective and non-nucleotide small molecule STING agonist/activator with pEC50 and pIC50 of 7.5 and 9.5 respectively.
STING agonist-31 V74319 STING agonist-31 2719001-44-0 STING agonist-31 is a STING agonist/activator with EC50s of 0.24 and 39.51 μM for h-STING and m-STING.
STING agonist-34 V74323 STING agonist-34 2913152-30-2 STING agonist-34 (Compound 12L) is a potent STING agonist/activator with IC50 of 1.15 μM and EC50 of 0.38 μM in THP1 cells.
STING agonist-38 V100143 STING agonist-38 2850251-27-1 STING agonist-38 (Compound 58) is a potent agonist of STING with an EC50 of 0.05 μM in THP1 cells.
STING agonist-42 V145351 STING agonist-42 2942231-48-1 STING agonist-42 is a potent STING agonist.
STING agonist-44 V145352 STING agonist-44 3078213-34-7 STING agonist-44 is a highly potent and selective STING agonist that induces IRF expression with an EC50 value of 5.68 in THP1 cells and 2.212 μM in RAW cells.
STING agonist-45 V118948 STING agonist-45 2361424-97-5 STING agonist-45 is a selective STING agonist (EC50 = 0.28 μM).
STING agonist-46 V118464 STING agonist-46 3033532-05-4 STING agonist-46 is an orally effective STING agonist.
STING agonist-47 V117382 STING agonist-47 STING agonist-47 is a STING agonist with an EC50 of 0.72 μM and a Kd of 176 nM.
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