The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V2457 | STING inhbitor 1 | 727699-84-5 | SN-001 is a STING inhibitor (antagonist) with IC50 of 3.82 μM. |
|
V74322 | STING modulator-3 | 2839639-94-8 | STING modulator-3 is a STING inhibitor. |
|
V74324 | STING modulator-4 | 2839639-72-2 | STING modulator-4 (compound AIH05) is a competitive STING modulator with a Ki of 0.0933 μM for R232H STING. |
|
V74331 | STING modulator-5 | 2305940-22-9 | STING modulator-5 (compound 38) is a THP-1 antagonist (inhibitor) with pIC50 of 8.9. |
|
V87015 | STING modulator-7 | 702662-64-4 | STING modulator-7 (compound 132) is a regulator of STING. |
|
V93929 | STING-IN-10 | STING-IN-10 (P8) is a dual STING degrader and inhibitor with a DC50 value of 2.58 μM in THP-1 cells. | |
|
V74329 | STING-IN-4 | 2250374-27-5 | STING-IN-4 (Compound 1) is a STING inhibitor that can suppress the expression of STING, thereby reducing the activation of STING and nuclear factor-κB (NF-κB) signaling pathways. |
|
V74325 | STING-IN-5 | 2920064-17-9 | STING-IN-5 is a potent STING inhibitor that can suppress LSP-induced NO synthesis in macrophages with IC50 of 1.15 μM. |
|
V74316 | STING-IN-6 | 2305940-34-3 | STING-IN-6 (compound 50) is a potent STING inhibitor (antagonist) with pIC50 of 8.9. |
|
V74327 | STING-IN-7 | 899947-07-0 | STING-IN-7 (compound 21) is a potent STING inhibitor (antagonist) with IC50 of 11.5 nM. |
|
V87006 | STING-IN-8 | STING-IN-8 (Compound 15b) is a potent inhibitor of stimulator of interferon genes (STING) with an IC50 value of 0.121 μM for humans and 0.033 μM for mice. | |
|
V2458 | STING inhibitor 2 | 2249435-90-1 | STING inhbitor 2 ( SN-011; SN011) is a novel and potent inhibitor of STING with potential anti-inflammatory activity. |
|
V21450 | G10 | 702662-50-8 | STING agonist-1 (G10) is a human-specific STING agonist that elicits anti-viral effect against emerging alphaviruses. |
|
V31647 | STING agonist-3 | 2138299-29-1 | STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer. |
|
V31644 | STING agonist-4 | 2138300-40-8 | STING agonist-4 (diABZI STING agonist-2) is a novel and potent agonist of stimulator of Interferon Genes (STING) receptor with an apparent inhibitory constant (IC50) of 20 nM. |
|
V85458 | Ulevostinag (isomer 2) (MK-1454 (isomer 2)) | 2082743-99-3 | |
|
V85471 | Ulevostinag (isomer 3) (MK-1454 (isomer 3)) | 2082743-98-2 | |
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V85515 | Ulevostinag (isomer 4) (MK-1454 (isomer 4)) | 2082743-97-1 | |
|
V18802 | Cridanimod | 38609-97-1 | Cridanimod (XBIO-101;XBIO101; Virexxa) is a novel and potent immunomodulator and interferon inducer withantineoplastic activity. |
|
V51261 | c-di-AMP disodium | 2734909-87-4 | Sodium c-di-AMP (cyclic diadenylate) is a STING agonist that binds to STING, thereby activating the TBK3-IRF3 signaling pathway and triggering the production of type I IFN and TNF. |
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