The ER-membrane protein Stimulator of Interferon Genes (STING) can be activated by the 2'3'-cGAMP produced by the enzyme Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase (cGAS) in response to the binding of double-stranded DNA. To protect against microbial infection, it activates inflammatory cytokine and interferon (IFN) responses.
STING is an important cytosolic receptor for small nucleotides that is essential for both antiviral and anticancer immunity. The STING signaling pathway triggers anti-tumor immune responses and serves as a vital link between innate and adaptive immunity. In numerous studies for immunogenic tumor clearance, antiviral therapies, and vaccine adjuvants, STING agonists like endogenous cyclic dinucleotide (CDN) cyclic GMP-AMP (cGAMP) have been used.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V84938 | MSA-2-Pt | ||
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V78866 | NVS-STG2 | NVS-STG2 is a molecular glue targeting STING and can activate STING-mediated immune signaling. | |
|
V79086 | SAP-04 | SAP-04 is a potent orally bioactive STING agonist. | |
|
V74314 | SN-008 | 2249106-01-0 | SN-008 is a low activity analog of SN-011 and can be used as a negative control (NC). |
|
V41902 | SP-23 | 2762552-74-7 | SP-23 (SP23) is a novel, first-in-class and potent STING-targeting PROTAC degrader based on C-170 (STING inhibitor) with anti-inflammatory effects. |
|
V51740 | SR-717 | 2375420-34-9 | SR-717 free acid is a non-nuclear STING-like agonist/activator with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cells, respectively. |
|
V2205 | SR-717 lithium | 2375421-09-1 | SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities. |
|
V85347 | ssVACV-70mer sodium | ||
|
V74332 | STING agonist-13 | 2816929-48-1 | STING agonist-13 is a STING agonist that performs cancer immunity through STING-mediated immune activation. |
|
V86118 | STING agonist-14 | 2411100-70-2 | |
|
V74328 | STING agonist-17 | 2816929-47-0 | STING agonist-17 (compound 4a) is a potent STING agonist/activator with IC50 of 0.062 nM. |
|
V85372 | STING agonist-21 | 2375419-35-3 | |
|
V74313 | STING agonist-22 | 2408723-12-4 | STING agonist-22 (CF501) is a potent non-nucleotide STING agonist. |
|
V51054 | STING agonist-23 | 2361570-16-1 | STING agonist-23 (CF502) is a novel non-nucleotide-based STING agonist. |
|
V51055 | STING agonist-24 | 2408722-91-6 | STING agonist-24 (CF504) is a novel non-nucleotide-based STING agonist. |
|
V51053 | STING agonist-25 | 2408723-10-2 | STING agonist-25 (CF505) is a novel non-nucleotide-based STING agonist. |
|
V51057 | STING agonist-26 | 2868261-48-5 | STING agonist-26 (CF508) is a novel non-nucleotide-based STING agonist. |
|
V74320 | STING agonist-27 | 2868261-45-2 | STING agonist-27 (CF509) is a non-nucleotide small molecule STING agonist. |
|
V51056 | STING agonist-28 | 2868261-50-9 | STING agonist-28 (CF510) is a novel non-nucleotide-based STING agonist. |
|
V74330 | STING agonist-29 | 2868261-51-0 | STING agonist-29 (CF511) is a non-nucleotide small molecule STING agonist. |
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