Receptor-interacting protein (RIP) kinases are a class of threonine/serine protein kinases with distinct non-kinase regions and a comparatively conserved kinase domain. The RIPK family consists of seven members, RIPK1 to RIPK7, some of which have become important effectors of immunity against infection with a variety of bacterial, viral, and protozoal pathogens.
Both communicable and non-communicable disease processes depend on the cellular signaling molecules known as RIP kinases for homeostatic signaling. The early control of a wide range of pathogenic organisms requires the action of RIPK1, RIPK2, RIPK3, and RIPK7, which have emerged as important mediators of intracellular signal transduction including inflammation, autophagy, and programmed cell death.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V26347 | Necrostatin-2 racemate | 852391-15-2 | Necrostatin-2, formerly known as (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s, is a racemic mixture ofNecrostatin-2 that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation. |
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V50928 | Reduced haloperidol | 34104-67-1 | active metabolite of haloperidol |
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V3403 | RIPA-56 | 1956370-21-0 | RIPA-56 is a novel, highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with anIC50of 13 nM. |
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V76006 | RIPK1-IN-14 | 2919964-79-5 | RIPK1-IN-14 (Compound 41) is a potent RIPK1 inhibitor (antagonist) with IC50 of 92 nM. |
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V76004 | RIPK1-IN-16 | 2561431-77-2 | RIPK1-IN-16 is an orally bioactive and potent inhibitor of RIPK1. |
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V81302 | RIPK1-IN-17 | RIPK1/3-IN-1 (Compound 10) is an inhibitor (blocker/antagonist) of RIPK1 and RIPK3. | |
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V51583 | RIPK2 PROTAC degrader 1 | 2126803-41-4 | RIPK2 PROTAC degrader |
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V79125 | RIPK2/3-IN-1 | RIPK2/3-IN-1 is a potent dual RIPK2/3 kinase inhibitor (antagonist) with IC50s of 3 nM and 117 nM respectively. | |
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V81303 | RIPK3-IN-3 | RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). | |
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V76005 | RIPK3-IN-4 | 2304617-58-9 | RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. |
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V76459 | SZM679 | SZM679 is an orally bioactive and selective RIPK1 inhibitor (antagonist) with Kds of 8.6 nM and >5000 nM for RIPK1 and RIPK3, respectively. | |
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V28191 | WEHI-345 | 1354825-58-3 | WEHI-345 (WEHI345) is a novel, potent and selective RIPK2 inhibitor with therapeutic potential to treat NOD-driven inflammatory diseases. |
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