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    tw-37
    tw-37

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0005
    CAS #: 877877-35-5Purity ≥98%

    Description: TW-37 (TW37 or TW 37) is a novel and potent small-molecule inhibitor of Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.29 μM, 1.11 μM and 0.26 μM in cell-free assays, respectively. TW-37 attenuates BCL-2 activation and inhibits multiple BCL-2 family members including BCL-xL (Ki = 1,110 nmol/L) and MCL-1 (Ki = 260 nmol/L). It binds to the BCL-2 homology domain 3 (BH3) groove of BCL-2 preventing the heterodimerization of proapoptotic proteins (such as Bid, Bim, and Bad) with BCL-2 and subsequently allowing them to induce apoptosis. Recent studies indicate TW-37 is able to inhibit the growth of a broad range of cancer cells, since it induces S-phase cell cycle arrest with regulation of several important cell cycle related genes, including p27, p57, cyclin D1 and cyclin E.

    Reference: Cancer Res. 2009 Apr 1;69(7):2757-65; Mol Cancer Ther. 2009 Apr;8(4):893-903. 

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    Molecular Weight (MW)573.7
    FormulaC33H35NO6S
    CAS No.877877-35-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:     115 mg/mL (200.5 mM)
    Water:      <1 mg/mL (slightly soluble or insoluble)
    Ethanol:  4 mg/mL (7.0 mM)
    Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL


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    GeneralTW-37 shows a maximum tolerated dose (MTD) of 40 mg/kg for three i.v. injections in severe combined immunodeficient (SCID) mice when given alone
    Animal modelAthymic NCr-nu/nu mice bearing SK-Mel-147 melanoma xenografts
    FormulationTW-37 is resuspended in Tween 80/ethanol (1:1 ratio, diluted 10-fold with 0.9% saline before use).
    Dosages0 mg/kg
    AdministrationIntravenously (IV) or Intraperitoneally (IP) 
    ReferencesVerhaegen M, et al. Cancer Res. 2006, 66(23), 11348-11359.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    tw-37

    tw-37

    As an inhibitor of Bcl-2, TW-37 is effective to reduce cell viability in HG3-CLL cells. Incubating the cells with TW-37 in 96 well plates (3×104 cells per well) for 24h shows a dose-dependent inhibition of cell viability with EC50 value of 1.17μM
     

    tw-37


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