Size | Price | Stock | Qty |
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2mg |
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5mg |
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10mg |
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25mg |
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Other Sizes |
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Purity: ≥98%
Rupintrivir (AG-7088) is a novel, selective and irreversible rhinovirus 3C protease inhibitor potentially for the treatment of human rhinovirus-HRV infection. Rupintrivirvr inhibits the replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays with a mean EC50 of 0.023 μM.
ln Vitro |
Rupintrivirvr (AG7088), in H1-HeLa and MRC-5 cell protection assays, inhibited the replication of all HRV serotypes (48 of 48) tested, as well as that of related picornaviruses, such as coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11. The mean 50% effective concentration (EC50) was 0.023 μM (range, 0.003 to 0.081 μM) and the mean EC90 was 0.082 μM (range, 0.018 to 0.261 μM).
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ln Vivo |
Rupintrivirvr (AG7088) decreases the TH-2 cytokine IL-4 that is induced by RV in ex vivo HDM-sensitized mouse lung slices (PCLS)[2].
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References |
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Molecular Formula |
C31H39FN4O7
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Molecular Weight |
598.66
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Exact Mass |
598.28
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Elemental Analysis |
C, 62.19; H, 6.57; F, 3.17; N, 9.36; O, 18.71
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CAS # |
223537-30-2
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Appearance |
Solid powder
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SMILES |
O=C(OCC)/C=C/[C@@H](NC([C@H](CC1=CC=C(F)C=C1)CC([C@@H](NC(C2=NOC(C)=C2)=O)C(C)C)=O)=O)C[C@H]3C(NCC3)=O
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InChi Key |
CAYJBRBGZBCZKO-BHGBQCOSSA-N
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InChi Code |
InChI=1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1
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Chemical Name |
ethyl
(S,E)-4-((2R,5S)-2-(4-fluorobenzyl)-6-methyl-5-(5-methylisoxazole-3-carboxamido)-4-oxoheptanamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate
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Synonyms |
AG-7088; AG7088; AG 7088; Rupintrivir
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~50 mg/mL (~83.52 mM)
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (2.79 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. Solubility in Formulation 2: 10% DMSO+90% Corn Oil: ≥ 1.67 mg/mL (2.79 mM)  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.6704 mL | 8.3520 mL | 16.7040 mL | |
5 mM | 0.3341 mL | 1.6704 mL | 3.3408 mL | |
10 mM | 0.1670 mL | 0.8352 mL | 1.6704 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Chemical structure of AG7088.[1].In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50. td> |
In vitro activity of AG7088 against HRV serotypes.[1].In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50. td> |
Antiviral activity of AG7088 when added at various times after virus infection.[1].In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50. td> |