The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V78034 | Antimicrobial agent-11 | Antimicrobial agent-11 is a SARS-CoV-2 inhibitor (antagonist) with antimicrobial effect. | |
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V78035 | Antimicrobial agent-12 | Antimicrobial agent-12 is an effective antimicrobial agent with SARS-CoV-2 inhibitory activity. | |
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V54433 | Antioxidant agent-9 | 71835-79-5 | Antioxidant agent-9 is a bioactive peptide with the sequence Asp-Trp. |
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V54427 | Antiviral agent 25 | 2761367-25-1 | antiviral compound 25 (compound 6g) is a new non-peptide mimetic covalent inhibitor of SARS-CoV-2 3CLpro. |
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V53358 | Antiviral agent 5 | 2698336-82-0 | antiviral compound 5 is an intermediate for antiviral active molecules targeting 3C and 3CL proteases like: SARS-CoV-2 Mpro. |
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V54394 | Arbemnifosbuvir | 1998705-63-7 | Arbemnifosbuvir is a nucleoviral RdRp-associated nucleotidyl transferase (NiRAN) nonstructural protein 12 (nsp12) interfering drug. |
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V29059 | AT-9010 | 1261253-79-5 | AT-9010 is the triphosphate bioactive metabolite of AT-527 and is a potent inhibitor of NiRAN (a function essential for viral replication). |
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V28865 | AT-9010 tetrasodium | 1621884-18-1 | AT-9010 tetrasodium is the triphosphate bioactive metabolite of AT-527 and is a potent inhibitor of NiRAN (a function essential for viral replication). |
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V29256 | AT-9010 triethylamine | 2648089-95-4 | AT-9010 triethylamine is the triphosphate bioactive metabolite of AT-527 and is a potent inhibitor of NiRAN (a function essential for viral replication). |
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V52658 | Atazanavir-d5 | 1132747-14-8 | Atazanavir-d5 is the deuterium labelled form of Atazanavir. |
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V4316 | AVIPTADIL Acetate | 40077-57-4 | Aviptadil (Vasoactive Intestinal Peptide) is a novel analog of vasoactive intestinal polypeptide (VIP) with the potential for the treatment of erectile dysfunction. |
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V76074 | Aviptadil acetate (Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine)) | 1444827-29-5 | Aviptadil acetate is a vasoactive intestinal polypeptide (VIP) analogue with strong vasodilatory effects. |
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V79742 | Azelastine-13C,d3 hydrochloride (Azelastine 13C-d3 hydrochloride) | Azelastine-13C,d3 ( HCl) is a 13C (carbon 13)-labeled deuterated form of Azelastine HCl. | |
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V54385 | Bamlanivimab (Anti-Human SARS-CoV-2) | 2423943-37-5 | Bamlanivimab (Anti-Human SARS-CoV-2) was the first COVID-19 monoclonal antibody (mAb) to receive Emergency Use Authorization (EUA) from the U.S. |
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V54371 | Bebtelovimab (LY-3853113; LY-COV1404) | 2578319-11-4 | Bebtelovimab is a human IgG1-λ2 antibody against SARS-CoV-2, specifically COVID-19. |
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V52349 | Beludavimab (BMS 4182137; VIR 7832) | 2423016-74-2 | Beludavimab (BMS 4182137; VIR 7832) is a monoclonal antibody (mAb) directed against the SARS-CoV-2 spike glycoprotein. |
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V52348 | Bemnifosbuvir (AT-511) | 1998705-64-8 | Bemnifosbuvir is a potent orally bioactive HCV (hepatitis C virus) viral replication inhibitor. |
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V41681 | Bemnifosbuvir hemisulfate (RG-6422; AT-527) | 2241337-84-6 | Bemnifosbuvir hemisulfate (RG-6422; AT-527), the hemisulfate salt of AT-511, is a guanosine nucleotide prodrug and orally bioactive HCV viral replication inhibitor. |
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V52732 | Boceprevir-d9 (EBP 520-d9; SCH 503034-d9) | 1256751-11-7 | Boceprevir-d9 is the deuterium labelled form of Boceprevir. |
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V52330 | Bofutrelvir (FB2001) | 2103278-86-8 | Bofutrelvir (FB2001) is an inhibitor (blocker/antagonist) of Mpro, the main protease of SARS-CoV-2, with IC50 of 53 nM and EC50 of 0.53 μM. |
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