The coronavirus (CoV) that causes severe acute respiratory syndrome, or SARS, is called SARS-CoV. CoVs, which are enveloped viruses with positive-sense, single-stranded RNA and can target the human respiratory system to spread disease, include not only the SARS virus but also MERS and SARS-CoV-2, which is the source of COVID-19.
The spike (S), membrane (M), envelope (E), and nucleocapsid (N) proteins are the four main structural proteins of CoVs. By binding to a cellular receptor (ACE2 for SARS-CoV and SARS-CoV-2, DPP4 for MERS-CoV), an S protein mediates the CoV entry into host cells, which is followed by the fusion of the virus and host cell membranes. Following entry, a large number of nonstructural proteins, including Mpro (main protease or 3CLpro), PLpro (papain-like protease), and RdRp (RNA-dependent RNA polymerase), participate in genome replication and subgenomic RNA transcription.The structural proteins are then translated, put together into mature virions, and exocytosed to release them via vesicles. It is noteworthy that a protease known as TMPRSS2 (transmembrane protease, serine 2), which cleaves S protein, plays crucial roles throughout the entire life of CoVs (such as attachment, assembling, and release). For the treatment of diseases brought on by CoVs, all the proteins and subcellular structures involved in the life cycle of CoVs are promising targets.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V76073 | X77 | 2455518-33-7 | X77 is a potent non-covalent inhibitor of SARS-CoV-2 protease (SARS-CoV-2 Mpro). |
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V38794 | XP-59 | 890402-73-0 | XP-59 is a potent SARS-CoV Mpro inhibitor (antagonist) with Ki of 0.1 nM. |
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V54403 | XR8-69 | 2817811-10-0 | XR8-69 is a SARS-CoV-2 PLpro inhibitor that displays low micromolar antiviral potency in SARS-CoV-2-infected human cells. |
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V76075 | XR8-89 | 2817811-16-6 | XR8-89 is a potent papain-like (PLpro) inhibitor (antagonist) with IC50 of 0.1 μM. |
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V54398 | Z-Arg-Leu-Arg-Gly-Gly-AMC | 167698-69-3 | Z-Arg-Leu-Arg-Gly-Gly-AMC is a bioactive peptide substrate of SARS-CoV PLpro. |
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V73065 | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) | 371167-61-2 | Z-Leu-Leu-Leu-fluoromethyl ketone (Z-LLL-FMK) is a cysteine protease inhibitor. |
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V35097 | Z-LVG-CHN2 | 119670-30-3 | Z-LVG-CHN2 is an intracellular irreversible inhibitor of cysteine protease. |
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V81768 | Z795161988 | Z795161988 is an inhibitor (blocker/antagonist) of SARS-CoV-2 Nsp14 N7-methyltransferase (IC50= 2.2 μM). | |
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V54392 | Zevotrelvir | 2773516-53-1 | Zevotrelvir (compound 52) is a coronavirus inhibitor (antagonist) with IC50 ranges of <0.1 μM and <0.1mM for 229E hCoV and SARS-CoV-23C-like (3CL) proteases, respectively. |
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V54401 | ZINC475239213 | 2871002-89-8 | ZINC475239213 is an inhibitor (blocker/antagonist) of SARS-CoV-2 Nsp14 N7-methyltransferase (IC50= 6 μM). |
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V81776 | ZINC61142882 | ZINC61142882 is an inhibitor (blocker/antagonist) of SARS-CoV-2 Nsp14 N7-methyltransferase (IC50= 6 μM). | |
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V73446 | ZL(D-Val)G-CHN2 | ZL(D-Val)G-CHN2 is the isomer of Z-LVG-CHN2, which is an intracellular irreversible cysteine protease inhibitor. |
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