A protein with two distinct functions, -catenin controls both the coordination of gene transcription and cell-cell adhesion. The CTNNB1 gene in humans encodes the CTNNB1 protein. In the Wnt signaling pathway, -catenin functions as an intracellular signal transducer as a subunit of the cadherin protein complex.It is a homolog of -catenin and a member of the catenin protein family. Hepatocellular carcinoma, colorectal carcinoma, lung cancer, malignant breast tumors, ovarian, and endometrial cancer are just a few of the cancers that have been linked to mutations and overexpression of -catenin. The beta-catenin destruction complex, and in particular the adenomatous polyposis coli (APC) protein, which is encoded by the tumor-suppressing APC gene, regulates and annihilates -catenin. As a result, genetic APC gene mutation is strongly associated with cancers, particularly colorectal cancer brought on by familial adenomatous polyposis (FAP).
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V26036 | MSAB | 173436-66-3 | MSAB is a novel and potent inhibitor of Wnt/β-catenin signaling withanticancer activity. |
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V51041 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide | 883715-23-9 | N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide is a macamide extracted from Maca (Lepidium meyenii Walp). |
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V3200 | NCB-0846 | 1792999-26-8 | NCB-0846 (NCB0846) is a novel, first orally bioavailable small molecule inhibitor of Wntthat inhibitsTNIK (TRAF2 and NCK-Interacting Kinase)with IC50 value of 21 nM. |
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V27702 | PNU-74654 | 113906-27-7 | PNU-74654 (PNU74654) is a novel inhibitor of Wnt/β-catenin pathway (IC50 = 129.8 μM), acting byinhibiting the interaction between ß-catenin and T cell factor 4 (Tcf4), and disrupting the Wnt signaling pathway. |
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V2690 | PRI-724 | 1422253-38-0 | PRI-724 (an analog of ICG 001 and a prodrug of C-82)is a novel, potent an specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. |
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V7131 | Prinaberel (ERB041) | 524684-52-4 | Prinaberel, formerly known as ERB-041, is a biochemical which acts as a highly selective agonist of the ERβ subtype of the estrogen receptor. |
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V51023 | Prodigiosin HCl | 56144-17-3 | Prodigiosin (Prodigiosine) HCl, a natural red pigment, is a biologically active secondary metabolite (SM, chemical compound). |
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V4111 | Pyrvinium | 3546-41-6 | Pyrvinium is an FDA-approved antihelmintic drugfor pinworms, it inhibitsWNTpathway signaling. |
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V12294 | RCM-1 | 339163-65-4 | RCM-1 is a novel and potent nontoxic FOXM1 inhibitor, which is able to inhibit goblet cell metaplasia and excessive mucus production. |
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V1861 | Salinomycin (Procoxacin) | 53003-10-4 | Salinomycin (also known as AHR-3096, or Procoxacin) is a potent antibacterial and coccidiostat ionophore therapeutic agent with potential anticancer activities by targeting stem cells. |
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V7468 | SKL2001 free base | 909089-13-0 | SKL2001 (SKL-2001) is a novel and potent agonist of Wnt/β-catenin signaling pathway with antitumor activity. |
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V37621 | SM04554 (Dalosirvat) | 1360540-81-3 | SM04554(Dalosirvat, Wnt pathway activator 1), a novel activator of Wnt with an IC50s of 28-29 nM,is an experimental drug that shows promise for treating androgenetic alopecia (male pattern baldness). |
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V16012 | Tegatrabetan (BC2059) | 1227637-23-1 | Tegatrabetan(also known as Tegavivint; BC-2059; BC 2059;BC2059) is an orally bioavailable and potent β-catenin inhibitor with potential anticancer activity. |
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V51026 | Teplinovivint | 1428064-91-8 | Teplinovivint is a potent inhibitor of the wnt/β-catenin signaling pathway. |
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V3007 | WAY-262611 | 1123231-07-1 | WAY-262611 (WAY262611) is a novel agonist of the wingless β-Catenin pathway with the potential forthe treatment of bone disorders. |
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V51018 | Wnt/β-catenin agonist 2 | 943820-93-7 | Wnt/β-catenin agonist 2 is a potent Wnt agonist. |
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V51019 | Wnt/β-catenin agonist 4 | 912784-79-3 | Wnt/β-catenin agonist 4 (analogue 83) is a Wnt agonist that activates/agonizes Wnt/β-catenin signaling. |
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