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STAT

STAT

The cytoplasmic protein family STAT controls a variety of cellular processes, including cell growth, survival, and differentiation. The Janus kinase family of transcription factors is activated, and dysregulation of this pathway, which promotes angiogenesis, tumor survival, and immunosuppression, is frequently seen in primary tumors. Gene knockout studies have shown that STAT proteins are important for immune system development and operation, immune tolerance maintenance, and tumor surveillance.

STAT related products

Structure Cat No. Product Name CAS No. Product Description
PMMB-187 V98051 PMMB-187 2162952-37-4 PMMB-187 is a selective STAT3 inhibitor with IC50 of 1.81 μM in MDA-MB-231 cells.
S3I-201 (NSC 74859) V1378 S3I-201 (NSC 74859) 501919-59-1 S3I-201 (also called S3I201;NSC74859;S3I 201;NSC-74859) is a cell permeable and selective Stat3 inhibitor with potential anticancer activity.
SH-4-54 V1385 SH-4-54 1456632-40-8 SH-4-54 (SH 454;SH4-54; SH454;SH-454) is anovel and potent STAT inhibitor with potential antineoplastic activity.
Smad2/3-IN-1 V87048 Smad2/3-IN-1 Smad2/3-IN-2 (Compound 3) is an inhibitor of TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathways with IC50 of 90 nM and 20 nM, respectively.
Smad2/3-IN-2 V87047 Smad2/3-IN-2 Smad2/3-IN-2 (Compound 3) is an inhibitor of TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathways with IC50 of 90 nM and 20 nM, respectively.
STAT3 HiBiT degrader 1 V104628 STAT3 HiBiT degrader 1 2767166-30-1 STAT3 HiBiT Degrader 1 is a STAT3 HiBiT degrader with DC50 ＜ 0.05 μM in A549 cells.
STAT3-IN-21, cell-permeable, negative control V86011 STAT3-IN-21, cell-permeable, negative control 400628-17-3
STAT3-IN-25 V87040 STAT3-IN-25 2591440-75-2 STAT3-IN-25 (compound 4c) is an orally active, potent inhibitor of STAT3 dual phosphorylation.
STAT3-IN-28 V87058 STAT3-IN-28 STAT3-IN-28 (compound 18) is a STAT3 inhibitor.
STAT3-IN-29 V87062 STAT3-IN-29 2256751-16-1 STAT3-IN-29 (Compound B20) is an inhibitor of STAT3.
STAT3-IN-31 V98284 STAT3-IN-31 STAT3-IN-31 (compound K2071) is a STATtic-derived STAT3 and mitotic inhibitor.
STAT3-IN-32 V99606 STAT3-IN-32 2591440-71-8 STAT3-IN-32 (compound 4c) is an orally available dual phosphorylation inhibitor of STAT3.
STAT3-IN-34 V97865 STAT3-IN-34 STAT3-IN-34 (Compound 15E) is a STAT3 inhibitor that inhibits the nuclear translocation and transcriptional regulatory activity of STAT3.
STAT3-IN-35 V97085 STAT3-IN-35 2849535-96-0 STAT3-IN-35 is a STAT3 inhibitor that binds to the SH2 domain.
STAT3-IN-36 V104396 STAT3-IN-36 3055766-74-7 STAT3-IN-36 (compound 11g) is a triple-target inhibitor targeting LRPPRC, STAT3, and CDK1 with anticancer activity.
STAT3-IN-37 V104859 STAT3-IN-37 3055844-98-6 STAT3-IN-37 (Compound 101) is a STAT3 inhibitor with IC50 of 15 nM (measured by DNA-HTRF assay) or 2 nM (measured by human whole blood SOCS3 qPCR assay).
STAT3-IN-38 V104788 STAT3-IN-38 3033049-16-7 STAT3-IN-38 (Compound 4m) is a STAT3 inhibitor (KD for rhSTAT3: 45.33 µM) and a derivative of Celastrol.
STAT3-IN-39 V105306 STAT3-IN-39 3037596-35-0 STAT3-IN-39 (Compound 10K) is an orally available STAT3 inhibitor with good inhibitory activity against STAT3 phosphorylation with IC50 of 0.47 μM in NIH-3T3 cells.
STAT3-IN-7 V51608 STAT3-IN-7 1313019-65-6 STAT3-IN-7 is a model of sorafenib that effectively inhibits STAT3 phosphorylation.
STAT6-IN-4 V87053 STAT6-IN-4 3033742-14-9 STAT6-IN-4 (78) is a STAT6 inhibitor with an IC50 value of 0.34 μM.
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