The crucial cell membrane protein known as P-glycoprotein (P-gp), also referred to as multidrug resistance protein 1 (MDR1), is responsible for expelling a variety of foreign substances. It is an ATP-dependent efflux pump with a broad substrate specificity, to put it more precisely. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood-brain barrier and blood-testis barrier, where it pumps them back into the capillaries.Additionally, some cancer cells overexpress P-gp, making these cancers multi-drug resistant. P-gp is a broad substrate specificity ATP-dependent drug efflux pump for xenobiotic compounds. It controls the reduced drug accumulation in cells with multiple drug resistance and frequently controls the emergence of anticancer drug resistance. The blood-brain barrier uses this protein as a transporter as well.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
|
V74227 | Pepluanin A | 670257-89-3 | Pepluanin A is a natural compound extracted from Euphorbia euphorbia. |
|
V74220 | Reversin 121 | 174630-04-7 | Reversin 121 is a P-glycoprotein (P-glycoprotein) inhibitor. |
|
V74212 | Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) | 174630-05-8 | Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. |
|
V71226 | Risperidone-d4 (R 64 766-d4) | 1020719-76-9 | Risperidone-d4 is the deuterated form of Risperidone. |
|
V1950 | SC144 | 895158-95-9 | SC144 is a first-in-class small-molecule inhibitor of gp130 with oral activity in ovarian cancer. |
|
V1295 | Tariquidar (XR9576) | 206873-63-4 | Tariquidar (formerly XR9576;D06008;XR-9576;D-06008) is a potent and selective noncompetitive inhibitor of P-glycoprotein (P-gp) with potential antineoplastic activity. |
|
V74218 | Tariquidar dihydrochloride (XR9576 dihydrochloride) | 1992047-62-7 | Tariquidar diHCl (XR9576 diHCl) is a potent and specific P-glycoprotein (P-gp) inhibitor (antagonist) with Kd of 5.1 nM. |
|
V2575 | Tariquidar methanesulfonate hydrate (XR9576) | 625375-83-9 | Tariquidar methanesulfonate hydrate (formerly also known as XR9576) is a novel potent and selective noncompetitive inhibitor of P-glycoprotein (P-gp) with Kd of 5.1 nM in CHrB30 cell line, it reverses drug resistance in MDR cell Lines. |
|
V11958 | Valspodar (PSC833) | 121584-18-7 | Valspodar (PSC833; SDZ-PSC 833; PSC-833), a cyclosporin-A analog, is a potent and selective inhibitor/modulator of P-glycoprotein (P-gp or MDR-1, an efflux transporter) being investigated as a potential anti-cancer drug and chemosensitizer. |
|
V74214 | WS-898 | 2891562-77-7 | WS-898 is a potent ABCB1 inhibitor that can reverse paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2 and HEK293/ABCB1 cells (IC50 = 5.0, 3.67 and 3.68 nM). |
|
V74215 | YS-370 | 2470908-79-1 | YS-370 (compound 44) is a specific, orally bioactive P-glycoprotein (P-gp) inhibitor. |
|
V2581 | Zosuquidar (LY-335979) | 167354-41-8 | Zosuquidar (formerly also known as LY335979) is a novel and potent inhibitor P-glycoprotein (P-gp) and modulator of P-gp-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. |
|
V1294 | Zosuquidar (RS 33295-198; LY335979) 3HCl | 167465-36-3 | Zosuquidar3HCl(formerly D-06387; D06387; RS33295198;LY335979; LY-335979;RS-33295198),the trihydrochloride salt of zosuquidar, is a novel and potent inhibitor P-glycoprotein (P-gp) and modulator of P-gp-mediated multi-drug resistance with potential antitumor activity. |
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