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    (R)-baclofen (STX209)
    (R)-baclofen (STX209)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1291
    CAS #: 69308-37-8Purity ≥98%

    Description: (R)-baclofen (formerly STX-209; STX209; STX 209), a derivative of gamma-aminobutyric acid, is a selective GABAB receptor agonist that has been primarily used to treat spasticity. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing. It acts at spinal and supraspinal sites, reducing excitatory transmission. GABAB receptors are metabotropic receptors which produce slow inhibitory signals.   

    References: J Neurochem. 1986 Sep;47(3):898-903; Lancet. 1984 May 12;1(8385):1078.

    Related CAS No.: 63701-55-3 [(R)-Baclofen HCl]; 847353-30-4 (Arbaclofen placarbil); 69308-37-8 (Arbaclofen); 

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    Molecular Weight (MW)213.66
    FormulaC10H12ClNO2    
    CAS No.69308-37-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 8 mg/mL (37.4 mM)
    Water:<1 mg/mL
    Ethanol:<1 mg/mL
    SMILESClC1=CC=C([[email protected]](CC(O)=O)([H])CN)C=C1
    SynonymsSTX209; STX-209; STX 209; 


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    In Vitro

    In vitro activity: Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.

    In Vivo(R)-Baclofen (STX209) suppresses audiogenic seizures in the Fmr1-knockout mouse on the seizure-resistant C57BL/6 background with an effective dose of 1 mg/kg; Acute intraperitoneal administration of (R)-Baclofen (STX209) significantly reduces the percent of mice displaying seizures (seizure incidence), with a minimum effective dose (MED) of 1.5 mg/kg.
    Animal modelMice
    Formulation & Dosage1, 1.5 mg/kg; i.p.
    References

    J Neurochem. 1986 Sep;47(3):898-903; Lancet. 1984 May 12;1(8385):1078.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    (R)-baclofen
    Baclofen increases the paired pulse ratio of both EPSCs and IPSCs. J Physiol. 2003 Jan 15; 546(Pt 2): 439–453.
     
    (R)-baclofen
    Baclofen increases the c.v. of both EPSCs and IPSCs. J Physiol. 2003 Jan 15; 546(Pt 2): 439–453.
     
    (R)-baclofen
    Baclofen-mediated inhibition of EPSCs and IPSCs occurs via GABAB receptor activation. J Physiol. 2003 Jan 15; 546(Pt 2): 439–453.


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