Gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system of vertebrates, activates a group of receptors known as GABA receptors. GABAA and GABAB are the two classes of GABA receptors. GABAB receptors are G protein-coupled receptors, also known as metabotropic receptors, while GABAA receptors are ligand-gated ion channels, also known as ionotropic receptors. It has long been known that direct anion channel activation causes neurons to respond quickly to GABA, which is blocked by bicuculline and picrotoxin. The GABAA receptor is the name given to this channel later. Fast-acting GABA receptors belong to the Cys-loop ligand-gated ion channel family. GABAB receptors, originally identified based on their pharmacological properties, mediate a slow response to GABA.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V71815 | (E)-GABAB receptor antagonist 1 | 1611483-29-4 | (E)-GABAB receptor antagonist 1 is the trans structure of GABAB receptor antagonist 1. |
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V112514 | (S)-Baclofen hydrochloride | 63701-56-4 | (S)-Baclofen hydrochloride is a GABAB receptor agonist that can cross the blood-brain barrier. It is effective orally, with an IC50 value of 1.77 μM for GABAB receptors and 1564 μM for GABAA receptors. |
|
V70286 | (S)-Cipepofol ((S)-Ciprofol; (S)-HSK3486) | 1637741-59-3 | (S)-Cipepofol is the inactive isomer of Cipepofol. |
|
V112377 | 1-Anthramine | 610-49-1 | 1-Anthracene (1-aminoanthracene) is a fluorescent general anesthetic. |
|
V70288 | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) | 4641-57-0 | 1-Phenyl-2-pyrrolidinone (1-Phenylpyrrolidin-2-one) is a GABA analog that has sedative effects and can reduce exploratory behavior in rats at 50-100 mg/kg (intravenous injection). |
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V71853 | 12,14-Dichlorodehydroabietic acid | 65281-77-8 | 12,14-Dichlorodehydroabietic acid, a chlorinated resin acid, is a potent Ca2+-activated K+ (BK) channel opener. |
|
V71812 | 17β-Estradiol sulfate sodium (17β-Estradiol 3-sulfate sodium) | 4999-79-5 | 17β-Estradiol sulfate (sodium), known also as β-Estradiol 3-sulfate sodium salt, is a neuroactive steroid. |
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V71182 | 2'-O-Methylisoliquiritigenin | 51828-10-5 | 2'-O-Methylisoliquiritigenin can be extracted from Arachis and can upregulate the 5-HT, NE, DA and GABA signaling pathways, but has little effect on the NE pathway. |
|
V71844 | 2'MeO6MF | 89112-85-6 | 2'MeO6MF is a BBB (blood-brain barrier) permeable (penetrable) PAM (positive allosteric modulator) of α2β1γ2L and all α1-containing GABAA receptors. |
|
V107374 | 3-(4-Chlorophenyl)-4-hydroxybutyric acid sodium | 1346603-21-1 | Sodium 3-(4-chlorophenyl)-4-hydroxybutyrate is an inactive metabolite of the GABAB receptor agonist baclofen. |
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V71840 | 3-Aminopropylphosphinic acid (3-APPA; CGP 27492; CGA 147823) | 103680-47-3 | 3-Aminopropylphosphinic acid (3-APPA) is a phosphate analog of GABA and a potent and specific GABAB receptor agonist (activator). |
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V85020 | 3-Aminopropylphosphonic acid ((3-Aminopropyl)phosphonic acid) | 13138-33-5 | |
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V85426 | 3-Ethyl-3-methylthiolan-2-one | 103620-92-4 | |
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V105297 | 3-Hydroxy desalkylflurazepam | 17617-60-6 | 3-Hydroxydesalkylflurazepam is a benzodiazepine with potential sedative and anxiolytic effects. |
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V71817 | 3-Methyl-GABA | 1216629-00-3 | 3-Methyl-GABA is a potent GABA aminotransferase activator. |
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V71811 | 3-Methylglutaconic acid (β-Methylglutaconic acid) | 5746-90-7 | 3-Methylglutaconic acid is the major metabolite accumulated in 3-methylglutaric aciduria (MGTA). |
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V51181 | Etiocholanolone (5β-Androsterone) | 53-42-9 | Etiocholanolone (5β-Androsterone) is a testosterone excretion aid with anticonvulsant (antiepileptic/antiseizure) activity. |
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V117506 | 4''-Oxoavermectin B1a | 122831-73-6 | 4''-Oxoavermectin B1a is a synergist that targets GABA (γ-aminobutyric acid) and glutamate-gated chloride ion channels, and has insecticidal and acaricidal activities. |
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V70289 | 6-Aminonicotinic acid | 3167-49-5 | 6-Aminonicotinic acid is a GABAA receptor agonist (activator) with Ki of 4.4 nM. |
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V106074 | 6-Methoxyflavanone | 3034-04-6 | 6-Methoxyflavanone (6-MeOF) is an orally active flavonoid. |
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