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| Other Sizes |
| Targets |
1-Phenyl-2-pyrrolidinone is a heterocyclic organic compound. While specific molecular targets have not been extensively characterized, pyrrolidinone-containing compounds are known to exhibit various biological activities.
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| ln Vitro |
In vitro, 1-phenyl-2-pyrrolidinone and related pyrrolidinone compounds have been shown to exhibit various biological activities, including antimicrobial, anticancer, and anti-inflammatory properties. The compound's pyrrolidinone core structure is a key pharmacophore for these activities.
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| ln Vivo |
No detailed in vivo activity data are publicly available for 1-phenyl-2-pyrrolidinone.
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| Enzyme Assay |
In vitro assays for 1-phenyl-2-pyrrolidinone are performed to evaluate its biological activities. Antimicrobial activity is assessed by measuring the inhibition of bacterial or fungal growth. Anticancer activity is assessed by measuring the inhibition of cell proliferation and the induction of apoptosis in cancer cell lines. Anti-inflammatory activity is assessed by measuring the inhibition of pro-inflammatory cytokine production.
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| Cell Assay |
In vitro cell-based assays are conducted to evaluate the effects of 1-phenyl-2-pyrrolidinone on cell viability and inflammation. Cells are treated with the compound, and cell viability is assessed using standard assays such as MTT or CCK-8. Inflammatory markers are measured by ELISA.
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| Animal Protocol |
No detailed in vivo animal study protocols are publicly available for 1-phenyl-2-pyrrolidinone.
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| ADME/Pharmacokinetics |
No detailed pharmacokinetic data are publicly available for 1-phenyl-2-pyrrolidinone.
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| Toxicity/Toxicokinetics |
No specific toxicity data are publicly available for 1-phenyl-2-pyrrolidinone.
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| References | |
| Additional Infomation |
1-Phenyl-2-pyrrolidinone (N-Phenyl-2-pyrrolidinone) is a heterocyclic organic compound with a pyrrolidinone core structure. It is a compound useful in organic synthesis and belongs to a class of compounds that exhibit potent biological activities and excellent luminescent properties. Pyrrolidinone-containing compounds play important roles in the development of new drugs and optoelectronic materials. The compound is a valuable research tool for studying the chemistry and biology of pyrrolidinone-containing compounds. It is not approved for human therapeutic use and is strictly for research purposes.
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| Molecular Formula |
C10H11NO
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|---|---|
| Molecular Weight |
161.20
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| Exact Mass |
161.084
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| CAS # |
4641-57-0
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| PubChem CID |
78375
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| Appearance |
White to off-white solid powder
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| Density |
1.1±0.1 g/cm3
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| Boiling Point |
355.5±11.0 °C at 760 mmHg
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| Melting Point |
67-69 °C(lit.)
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| Flash Point |
174.7±10.5 °C
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| Vapour Pressure |
0.0±0.8 mmHg at 25°C
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| Index of Refraction |
1.578
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| LogP |
1.39
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
1
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| Rotatable Bond Count |
1
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| Heavy Atom Count |
12
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| Complexity |
173
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| Defined Atom Stereocenter Count |
0
|
| SMILES |
C1CC(=O)N(C1)C2=CC=CC=C2
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| InChi Key |
JMVIVASFFKKFQK-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C10H11NO/c12-10-7-4-8-11(10)9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2
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| Chemical Name |
1-phenylpyrrolidin-2-one
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: 100 mg/mL (620.35 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (15.51 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.51 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (15.51 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.2035 mL | 31.0174 mL | 62.0347 mL | |
| 5 mM | 1.2407 mL | 6.2035 mL | 12.4069 mL | |
| 10 mM | 0.6203 mL | 3.1017 mL | 6.2035 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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