| Size | Price | Stock | Qty |
|---|---|---|---|
| 50mg |
|
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| 100mg |
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| Other Sizes |
|
| Targets |
AChE
|
|---|---|
| ln Vitro |
After three hours of culture, acephate starts to decrease basal androgen output in rat immature Leydig cells in a dose-dependent manner, commencing at 0.5 μM. At 50 μM, acephate dramatically reduces the production of testosterone induced by 8-Br-cAMP and luteinizing hormone. At 50 μM, acephate dramatically reduces progesterone-mediated androgen production [1].
|
| ln Vivo |
Sperm motility and count reduced at doses of 14 and 28 mg/kg/day when adult male mice were administered Acephate at 0, 7, 14, and 28 mg/kg/day for 28 days [1].
|
| References |
[1]. Yiyan Wang, et al. Acephate interferes with androgen synthesis in rat immature Leydig cells. Chemosphere. 2020 Apr;245:125597.
|
| Molecular Formula |
C4H10NO3PS
|
|---|---|
| Molecular Weight |
183.17
|
| CAS # |
30560-19-1
|
| Related CAS # |
Acephate-d3;2140327-70-2
|
| SMILES |
CC(NP(OC)(SC)=O)=O
|
| Solubility (In Vitro) |
H2O: 125 mg/mL (682.43 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (545.94 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.4594 mL | 27.2970 mL | 54.5941 mL | |
| 5 mM | 1.0919 mL | 5.4594 mL | 10.9188 mL | |
| 10 mM | 0.5459 mL | 2.7297 mL | 5.4594 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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