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Purity: ≥98%
Bavachinin (BVC; 7-O-Methylbavachin; Bavachinin A) is a naturally occuring compound isolated from the fruit of the traditional Chinese herb Fructus Psoraleae (FP). It has potent anti-angiogenic activity.
| ln Vivo |
In nude mice, babachinin (5 mg/kg; intraperitoneal injection; seven consecutive days) can impede kit KB tumor growth and angiogenesis [2]. Tumors in mice can be treated with bevacidin (50 mg/kg; intraperitoneal injection; seven consecutive days) [
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| Cell Assay |
Immunofluorescence[4]
Cell Types: A549 Cell Tested Concentrations: 25 μM, 50 μM Incubation Duration: 24 h Experimental Results: Shows PPARγ protein levels in the cytoplasm and cytoplasm Bavachinin (25, 50 μM; 24 h) increases PPARγ protein expression[4] . The cell nuclei were Dramatically elevated. |
| Animal Protocol |
Animal/Disease Models: Athymic nude mice were inoculated subcutaneously (sc) (sc) with KB cells [2]
Doses: 5 mg/kg Route of Administration: intraperitoneal (ip) injection Experimental Results: It demonstrated that the tumor volume was Dramatically diminished by 40.06%, and the lumen size and blood vessels were less. 3]. Animal/Disease Models: Asthma mice [3] Doses: 50 mg/kg Route of Administration: po (oral gavage) Experimental Results: demonstrated significant inhibition of serum IL-4 and IgE levels. |
| References |
[1]. Chen X, et al. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. FEBS Lett. 2013 Sep 17;587(18):2930-5.
[2]. Nepal M, et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α. Eur J Pharmacol. 2012 Sep 15;691(1-3):28-37. [3]. Chen X, et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs. Cell Mol Immunol. 2013 Nov;10(6):497-505. [4]. Lu-Na Ge, et al. Bavachinin exhibits antitumor activity against non small cell lung cancer by targeting PPARγ. Mol Med Rep. 2019 Sep;20(3):2805-2811. [5]. Li Feng, et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice. Diabetologia. 2016 Jun;59(6):1276-86. |
| Molecular Formula |
C21H22O4
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|---|---|
| Molecular Weight |
338.3970
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| CAS # |
19879-30-2
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| SMILES |
O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=C1C=C(C/C=C(C)/C)C(OC)=C3
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| InChi Key |
VOCGSQHKPZSIKB-FQEVSTJZSA-N
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| InChi Code |
InChI=1S/C21H22O4/c1-13(2)4-5-15-10-17-18(23)11-20(14-6-8-16(22)9-7-14)25-21(17)12-19(15)24-3/h4,6-10,12,20,22H,5,11H2,1-3H3/t20-/m0/s1
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| Chemical Name |
(2S)-2,3-dihydro-2-(4-hydroxyphenyl)-7-methoxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one
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| Synonyms |
7-O-Methylbavachin
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~125 mg/mL (~369.39 mM)
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9551 mL | 14.7754 mL | 29.5508 mL | |
| 5 mM | 0.5910 mL | 2.9551 mL | 5.9102 mL | |
| 10 mM | 0.2955 mL | 1.4775 mL | 2.9551 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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