Neurohypophysial hormone arginine vasopressin (AVP) regulates body fluid homeostasis, causes vasoconstriction, and releases adrenocorticotropic hormone, among other things. Three subtypes of vasopressin receptors—designated V1a, V1b (or V3), and V2—mediate these physiological effects. They are all members of the large family of G-protein-coupled receptors that resemble rhodopsin.
The V1a receptor stimulates hepatic glycogenolysis, platelet aggregation, coagulation factor release, and cell contraction and proliferation. It is expressed in both neuronal and non-neuronal tissues, including the heart. The pituitary gland is the primary site of the V1b receptor subtype, which is responsible for stimulating the release of adrenocorticotropic hormone. The G protein alpha-subunit of the Gαq family (αq, q11, q14, α15/16) is the mechanism by which the V1a and V1b AVP receptors activate phospholipase C-β, raising the levels of calcium and IP3 in cells. On the other hand, the V2 receptor subtype is primarily found in the kidney, where it activates adenylyl cyclase and mediates the anti-diuretic effects of AVP via the heterotrimeric G protein Gs.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V79368 | F992 TFA | F992 TFA is an antidiuretic peptide and vasopressin (antidiuretic hormone) analog. | |
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V74546 | Invopressin (OCE-205) | 1488411-60-4 | Invopressin (Compound 42) is a vasopressin V1A receptor partial agonist (EC50= 1.0 nM). |
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V74533 | Lazuvapagon (SK-1404; KRP-N118) | 2379889-71-9 | Lazuvapagon (SK-1404) is a vasopressin V2 receptor agonist (activator) utilized in study/research of enuresis. |
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V4748 | Lixivaptan | 168079-32-1 | Lixivaptan (formerly known as VPA-985, WAY-VPA 985) is a novel, potent, selective and orally bioactive non-peptide antagonist of vasopressin receptor V2 with IC50 values of 1.2 and 2.3 nM for human and rat V2, respectively. |
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V1486 | Mozavaptan (OPC-31260) | 137975-06-5 | Mozavaptan (formerly known as OPC-31260; OPC-31260l; OPC31260; OPC31260l) is an orally bioactive, selective and competitive vasopressin receptor antagonist for both V1 and V2 receptors with anti-hypernatremic activity. |
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V26933 | OPC-21268 | 131631-89-5 | Fuscoside (OPC21268; OPC-21268) is a vasopressin 1 receptor antagonist (IC50 = 0.4 μM.) potentially for the treatment of heart failure and hypertension. |
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V83234 | RGH-122 | 2355304-05-9 | RGH-122 is an orally bioactive hV1a receptor antagonist with Ki of 0.3 nM and IC50 of 0.9 nM. |
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V76520 | Selepressin acetate (FE 202158 acetate) | Selepressin (FE 202158) acetate is a selective vasopressin V1A receptor agonist. | |
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V74530 | SKF 100398 (d(CH2)5Tyr(Et)VAVP) | 77453-01-1 | SKF 100398 (d(CH2)5Tyr(Et)VAVP) is an arginine vasopressin (AVP) analogue that works as a specific antagonist of the antidiuretic effects of exogenous and endogenous AVP. |
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V32785 | Terlipressin | 14636-12-5 | Terlipressin is a tube-active vasopressin analog and a selective vasopressin V1 receptor agonist (activator) that reduces splanchnic blood flow and portal pressure and controls acute variceal bleeding. |
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V16096 | Terlipressin acetate | 914453-96-6 | Terlipressin acetate is a tube-active vasopressin analog and a selective vasopressin V1 receptor agonist (activator) that reduces splanchnic blood flow and portal pressure and controls acute variceal bleeding. |
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V74529 | Terlipressin diacetate | 1884420-36-3 | Terlipressin acetate is a vasoactive vasopressin analog and a selective vasopressin V1 receptor agonist that reduces splanchnic blood flow and portal pressure and controls acute variceal bleeding. |
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V1485 | Tolvaptan (OPC-41061) | 150683-30-0 | Tolvaptan (formerly OPC41061; OPC-41061; trade names Samsca; Jinarc; Resodim) is a selective, competitive, orally bioavailable and nonpeptide antagonist of arginine vasopressin V2 receptor with anti-hypernatremic activity. |
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V74539 | Tolvaptan phosphate ester sodium | 942619-79-6 | Tolvaptan phosphate ester sodium is the prodrug of Tolvaptan and may be utilized in cardiac edema research. |
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V74545 | Val9-Oxytocin | 1021701-88-1 | Val9-Oxytocin is a complete antagonist of the vasopressin (1a) receptor. |
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V77457 | Vasopressin Dimer (anti-parallel) (TFA) | Vasopressin Dimer (anti-parallel) TFA is the antiparallel dimer of Vasopressin. | |
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V77458 | Vasopressin Dimer (parallel) (TFA) | Vasopressin Dimer (parallel) TFA is a parallel dimer of Vasopressin. |
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