Ras

ADC Related

ADC Antibody ADC Cytotoxin ADC Linker ADCs Drug-Linker Conjugates for ADC
Angiogenesis

5-alpha Reductase ALK Bcr-Abl BTK EGFR FAK FLT3 HER-2 HIF Src Syk VDA VEGFR
Anti-infection

Antibiotic Arenavirus Bacterial CMV EBV Enterovirus Filovirus Fungal Gli HBV HCV HCV Protease HIV HSV Influenza Virus Parasite RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease
Apoptosis

Apoptosis ASK Bcl-2 Caspase c-Myc c-RET Cytohesin DAPK Ferroptosis FKBP IAP Mdm2 p53 PD-1 PD-L1 PERK PKD Ras RIP kinase ROS Survivin Thymidylate Synthase TNF Receptor TNFa TRADD
Autophagy

Autophagy LRRK2 Mitophagy OGA ULK
Cell Cycle

Antifolate APC Aurora Kinase BMI-1 CDK Chk c-Myc Eukaryotic Initiation Factor G-quadruplex HDAC HSP Kinesin LIMK Mad2 Microtubule(Tubulin) Mps1 Nucleoside Antimetabolite/Analog Nur77 p21 PAK PERK PFKFB PLK PPAR Ras Rho ROCK SRPK TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2 3 Complex Bcr-Abl Cardiac Myosin Dynamin Gap Junction Protein HSP Integrin Kinesin Microtubule Associated MLCK Myosin PAK TACC3 Wntbeta-catenin
DNA Damage

ATM(ATR) CRISPR(Cas9) DNA alkylator DNA Stain DNA(RNA) Synthesis GAK HDAC HSP Nucleoside Antimetabolite(Analog) OGG1 p97 PARG PARP RAD51 RNR Sirtuin SMN Telomerase Topoisomerase
Endocrinology & Hormones

5-alpha Reductase ACE Adrenergic Receptor Androgen Receptor Aromatase Estrogenprogestogen Receptor Glucocorticoid Receptor GPR Mineralocorticoid Receptor RAAS THR TSH Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain EZH1 2 HDAC HIF Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK MAT MicroRNA MLL Pim PKC Protein Arginine Deiminase Sirtuin Small Interfering RNA (siRNA) SMYD

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Ras

Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs.All members of the Ras protein family are involved in signal transmission within cells and are members of the small GTPase protein class. The archetypal member of the Ras superfamily of proteins, which controls a variety of cell behaviors and is connected in three dimensions, is called Ras. Incoming signals cause Ras to become "switched on," which in turn causes other proteins to become "switched on," which in turn activates genes related to cell division, growth, and survival. Ras proteins that are permanently activated can therefore be produced as a result of mutations in the ras gene.Even in the absence of incoming signals, this can result in unwanted and excessive signaling within the cell. Overactive Ras signaling can eventually result in cancer because these signals cause cell growth and division. The most prevalent oncogenes in human cancer are the three Ras genes (HRAS, KRAS, and NRAS); Ras inhibitors are being researched as a potential treatment for cancer and other disorders where Ras overexpression occurs.

Ras related products

Cat No.	Product Name	CAS No.	Product Description
V74741	PROTAC KRAS G12C degrader-3	2768099-51-8	PROTAC KRAS G12C degrader-3 (Comp 283) is a potent KRAS G12C degrader that may be utilized in cancer-related research.
V74729	Rac1 Inhibitor W56	1095179-01-3	Rac1 Inhibitor W56 is residues 45-60 in Rac1.
V74731	Rac1-IN-3	380470-06-4	Rac1-IN-3 (Compound 2) is a Rac1 inhibitor (antagonist) with IC50 of 46.1 μM.
V74728	Ras modulator-1	623935-08-0	Ras modulator-1 is a Ras modulator.
V2502	Rasarfin	674359-73-0	Rasarfin is a novel dual Ras and ARF6 inhibitor,which blocks agonist-mediated internalization of AT1R and other GPCRs.
V2949	RBC8	361185-42-4	RBC8 is a novel and potent inhibitor of Ral GTPase with IC50 of 3.5 μM in H2122 cells and 3.4 μM in H358 cells.
V74725	RMC-4998	2642037-07-6	RMC-4998 is a molecular glue compound with good anti-tumor activity.
V74722	RMC-7977	2765082-12-8	RMC-7977 is a reversible tricomplex RAS inhibitor (antagonist) with broad-spectrum activity against mutant and wild-type (WT) KRAS, NRAS and HRAS variants.
V74740	RTIL 13	1009376-10-6	RTIL 13 is a potent dynamin GTPase inhibitor (antagonist) with IC50 of 2.3 µM for dynamin I GTPase.
V74705	SAH-SOS1A TFA	2896737-31-6	SAH-SOS1A TFA is a bioactive peptide-based inhibitor of the SOS1/KRAS protein interaction.
V74714	SOS1-IN-10	2758690-15-0	SOS1-IN-10 is a potent SOS1 inhibitor (antagonist) with IC50 of 13 nM against KRAS G12C-SOS1.
V74727	SOS1-IN-3	2359689-76-0	SOS1-IN-3 is a potent inhibitor of SOS1 with IC50 of 5 nM.
V74710	SOS1-IN-9	2758900-76-2	SOS1-IN-9 is a potent SOS1 inhibitor (antagonist) with IC50 of 116.5 nM against KRAS G12C-SOS1.
V74737	StRIP16	2761279-63-2	StRIP16, a bioavailable StRIP3 analog, is a double-stapled peptide that binds to Rab8a GTPase with a Kd of 12.7 μM.
V74703	TH-Z827	2847881-81-4	TH-Z827 is a mutant-selective KRAS(G12D) inhibitor (antagonist) with IC50 of 2.4 μM.
V28342	Y16	429653-73-6	Y16, formerly known as RhoA-IN-Y16, is a RhoA inhibitor, Y16 blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM).
V74719	Z62954982 (ZINC08010136)	1090893-12-1	Z62954982 (ZINC08010136) is a specific, cell-permeable (penetrable) Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (IC50=50 μM).
V5241	ZT-12-037-01	2328073-61-4	ZT-12-037-01 is a novel, potent, ATP-competitive and specific STK19-targeted inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively.
V29442	Methylophiopogonanone B	74805-91-7	Methylophiopogonanone B, a high isoflavone found in the roots of Ophiopogon japonicus, has high antioxidant capacity.
V3449	Sotorasib (AMG-510)	2296729-00-3	Sotorasib (AMG-510; AMG510; Lumakras; Lumykras) is a novel, first-in-class and covalent/irreversible inhibitor of KRAS G12C that has been approved by FDA on 5/28/2021 to treat non-small-cell lung cancer (NSCLC).