| Size | Price | |
|---|---|---|
| 500mg | ||
| 1g | ||
| Other Sizes |
| Targets |
mGluR5
|
|---|---|
| ln Vitro |
AZD 2066 (1-10 μM) hydrochloride inhibits Ca2+ responses with IC50 values of 27.2, 3.56, 96.2 and 380 nM in mGlu5/HEK cells and striatal, hippocampal and cortical cultures, respectively[4]. AZD 2066 (1-10 μM) hydrochloride inhibits DHPG bath-induced Ca2+ oscillatory responses and blocks the effects of DHPG or Quis in mGlu5/HEK cells[4].
|
| ln Vivo |
AZD 2066 (0.3-30 mg/kg, oral, 60 min) hydrochloride has a discriminative effect in rats[2]. AZD-2066 (10 µM, brain slice perfusion) hydrochloride alleviates dihydroxyphenylglycine (DHPG)-induced long-term depression (LTD) in mice treated with chronic social defeat stress (CSDS) via the BDNF/trkB signaling pathway[5]. AZD-2066 (5 mg/kg, intraperitoneal injection, 2 × 12 h) hydrochloride can alleviate the depressive behavior induced by chronic social defeat stress (CSDS) in mice[5].
|
| Animal Protocol |
Animal/Disease Models: Male Wistar rats (weighing 240-250 g)[2]
Doses: 0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg Route of Administration: Oral gavage (p.o.) Experimental Results: Caused full and dose-dependent AZD9272-appropriate responding. Animal/Disease Models: Depressive model (C57BL/6 mice were subjected to physical defeats that were generated by a CD-1 aggressor for 5 min every day for 10 days)[5] Doses: 5 mg/kg Route of Administration: Intraperitoneal injection (i.p.), 2 × 12 h Experimental Results: Increased social interaction ratio. Reversed time spent in interaction zone. Increased sucrose preference scores. |
| References |
|
| Molecular Formula |
C19H17CL2N5O2
|
|---|---|
| Molecular Weight |
418.28
|
| CAS # |
934338-70-2
|
| Related CAS # |
AZD 2066;934282-55-0
|
| SMILES |
ClC1=CC=CC(=C1)C1=CC([C@@H](C)OC2=NN=C(C3C=CN=CC=3)N2C)=NO1.Cl
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.3907 mL | 11.9537 mL | 23.9074 mL | |
| 5 mM | 0.4781 mL | 2.3907 mL | 4.7815 mL | |
| 10 mM | 0.2391 mL | 1.1954 mL | 2.3907 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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