Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin. The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1612 | TAI-1 | 1334921-03-7 | TAI-1 (TAI 1; TAI1) is a selective Hec1 (High expression in cancer 1) inhibitor with potential anticancer activity. |
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V1624 | Triclabendazole (CGA89317) | 68786-66-3 | Triclabendazole (also known as CGA-89317; CGA89317; EGA-230B; Fasinex; NVP-EGA-230; Egaten)is a benzimidazole-based anthelmintic and fasciolicidal agentthat acts as a tubulin inhibitor by binding to tubulin and impairing the intracellular transport mechanisms, thus interfering with protein synthesis. |
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V1621 | Vinblastine (Vincaleukoblastine) | 865-21-4 | Vinblastine (formerly NSC49842; NSC-49842;NSC 49842; Velban; Velsar; VLB; Vincaleukoblastine), a naturally occuring alkaloid isolated from the plant Vinca rosea Linn, is an approved anticancer drug acting as a potent mitotic inhibitor thatinhibits microtubule assembly/formation. |
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V1605 | Vincristine sulfate (Leurocristine) | 2068-78-2 | Vincristinesulfate (also known as Leurocristine; NSC67574; NSC-67574;Vincasar PFS, Oncovin, VCR), the sulfate salt ofVincristine which is a naturally occurring alkaloid isolated from the plant Vinca rosea Linn and an approved anticancer drug, is a potent inhibitor of microtubule polymerization by binding to tubulin with IC50 of 32 μM in a cell-free assay. |
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V1625 | Vinflunine Tartrate (F12158) | 1201898-17-0 | Vinflunine tartrate (formerlyBMS710485,F-12158, F12158,BMS-710485), the tartrate salt ofVinflunine,is a bi-fluorinatedanalog of the vinca alkaloid vinorelbine with potential antitumor activity. |
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V1615 | Vinorelbine ditartrate (KW-2307) | 125317-39-7 | Vinorelbine ditartrate (KW-2307; KW2307;Navelbine, Biovelbin, Eunades; Nor-5-anhydrovinblastine), the ditartrate salt of vinorelbine which is an antimitotic agent, is a tubulin inhibitor and microtubule stablizer approved for cancer treatment. |
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