• Other

    Other
  • CN

    CN
  • EU

    EU
  • USA

    USA
    • My cart
    In the shopping cart is not goods, to choose and buy!
    • Product Name
    • Size
    • Quantity
    • Amount
      Selected items : 0 pieces Total : CHECK OUT()
      Vinorelbine ditartrate (KW-2307)
      Vinorelbine ditartrate (KW-2307)

      Price：
      Market Price：

      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V1615
      CAS #: 125317-39-7Purity ≥98%

      Description: Vinorelbine ditartrate (KW-2307; KW2307; Navelbine, Biovelbin, Eunades; Nor-5'-anhydrovinblastine), the ditartrate salt of vinorelbine which is an antimitotic agent, is a tubulin inhibitor and microtubule stablizer approved for cancer treatment. It is a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) and has been used extensively for the treatment for various cancers such as breast cancer and non-small cell lung cancer. 

      References: Semin Oncol. 1989 Apr;16(2 Suppl 4):9-14; Eur J Cancer. 1999 Mar;35(3):512-20.

      Related CAS #: 125317-39-7 (tartrate)   105661-07-2 (tartrate 1:1)   71486-22-1 (free base)    

      Customer Validation
      Official Supplier of
      • VE
      • OF
      • YALE
      • hhmi
      • 香港大学
      Related Products
      Publications Citing InvivoChem Products
      • Physicochemical and Storage Information
      • Protocol
      • Quality Control Documentation
      • Related Biological Data
      • Customer Review
      Molecular Weight (MW)1079.11 
      FormulaC45H54N4O8.2C4H6O6 
      CAS No.125317-39-7 
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 100 mg/mL (92.7 mM) 
      Water: 100 mg/mL (92.7 mM) 
      Ethanol: 100 mg/mL (92.7 mM) 
      Other info

      Chemical Name: methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate bis((2R,3R)-2,3-dihydroxysuccinate)

      InChi Key: CILBMBUYJCWATM-PYGJLNRPSA-N

      InChi Code: InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;2*1-,2-/m011/s1

      SMILES Code: O=C(OC)[[email protected]@]1([[email protected]@]2(N(C3=C([[email protected]@]24CCN5CC=C[[email protected]@](CC)([[email protected]]1OC(C)=O)[[email protected]@]45[H])C=C(C(OC)=C3)[[email protected]]6(C[[email protected]]7([H])C=C(CN(CC8=C6NC9=C8C=CC=C9)C7)CC)C(OC)=O)C)[H])O.O=C([[email protected]@H]([[email protected]](C(O)=O)O)O)O.O=C([[email protected]@H]([[email protected]](C(O)=O)O)O)O

      Synonyms

      KW2307, Nor-5'-anhydrovinblastine ditartrate, vinorelbine tartrate, KW-2307, KW 2307, Navelbine, Biovelbin, Eunades


      • Molarity Calculator
      • Dilution Calculator
      • The molarity calculator equation

        Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

        • Mass
        • Concentration
        • Volume
        • Molecular Weight *
        • =
        • ×
        • ×
      • The dilution calculator equation

        Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

        This equation is commonly abbreviated as: C1V1 = C2V2

        • Concentration (start)
        • ×
        • Volume (start)
        • =
        • Concentration (final)
        • ×
        • Volume (final)
        • ×
        • =
        • ×
        • C1
        •  
        • V1
        •  
        • C2
        •  
        • V2
      In Vitro

      In vitro activity: Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc.

      In VivoIn vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. 
      Animal modelBladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts. 
      Formulation & DosageDissolved in Sterile 0.9% sodium chloride solution; 10 mg/kg; i.p. injection 
      References

      Semin Oncol. 1989 Apr;16(2 Suppl 4):9-14; Eur J Cancer. 1999 Mar;35(3):512-20. 

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      评论

        Home Prev Next Last page / pices

        发评论

        ×
        Your information is safe with us. * Required Fields.
        Products are for research use only;  We do not sell to patients
        Contact Us
        Contact Us
        Tel: 1-708-310-1919
        Fax: 1-708-557-7486
        Email: [email protected]
        Frequently Asked Questions
        Subscribe to our E-newsletter
        • Name*
        • *
        • E-mail*
        • *
        • instructions：
        • *
        Copyright 2020 InvivoChem LLC | All Rights Reserved
          Site map
        prompt
        Do you confirm the receipt?