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    Vinorelbine ditartrate (KW-2307)
    Vinorelbine ditartrate (KW-2307)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1615
    CAS #: 125317-39-7Purity ≥98%

    Description: Vinorelbine ditartrate (KW-2307; KW2307; Navelbine, Biovelbin, Eunades; Nor-5'-anhydrovinblastine), the ditartrate salt of vinorelbine which is an antimitotic agent, is a tubulin inhibitor and microtubule stablizer approved for cancer treatment. It is a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) and has been used extensively for the treatment for various cancers such as breast cancer and non-small cell lung cancer. 

    References: Semin Oncol. 1989 Apr;16(2 Suppl 4):9-14; Eur J Cancer. 1999 Mar;35(3):512-20.

    Related CAS #: 125317-39-7 (tartrate)   105661-07-2 (tartrate 1:1)   71486-22-1 (free base)    

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    Molecular Weight (MW)1079.11 
    FormulaC45H54N4O8.2C4H6O6 
    CAS No.125317-39-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (92.7 mM) 
    Water: 100 mg/mL (92.7 mM) 
    Ethanol: 100 mg/mL (92.7 mM) 
    Other info

    Chemical Name: methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((6R,8S)-4-ethyl-8-(methoxycarbonyl)-1,3,6,7,8,9-hexahydro-2,6-methanoazecino[4,3-b]indol-8-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate bis((2R,3R)-2,3-dihydroxysuccinate)

    InChi Key: CILBMBUYJCWATM-PYGJLNRPSA-N

    InChi Code: InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6,36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32)54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2,37(43)49)39(57-26(3)50)45(38,53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9,16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28-,37-,38+,39+,42+,43+,44-,45-;2*1-,2-/m011/s1

    SMILES Code: O=C(OC)[[email protected]@]1([[email protected]@]2(N(C3=C([[email protected]@]24CCN5CC=C[[email protected]@](CC)([[email protected]]1OC(C)=O)[[email protected]@]45[H])C=C(C(OC)=C3)[[email protected]]6(C[[email protected]]7([H])C=C(CN(CC8=C6NC9=C8C=CC=C9)C7)CC)C(OC)=O)C)[H])O.O=C([[email protected]@H]([[email protected]](C(O)=O)O)O)O.O=C([[email protected]@H]([[email protected]](C(O)=O)O)O)O

    Synonyms

    KW2307, Nor-5'-anhydrovinblastine ditartrate, vinorelbine tartrate, KW-2307, KW 2307, Navelbine, Biovelbin, Eunades


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    In Vitro

    In vitro activity: Vinorelbine inhibits microtubule assembly by inducing tubulin aggregation into spirals and paracrystals. Vinorelbine shows potent antiproliferative activity against a series of tumor cells, including human melanoma, non-small-cell lung cancer, breast cancer, etc.

    In VivoIn vivo, Vinorelbine also shows antitumour activity against a series of subcutaneously-implanted human tumour xenografts. 
    Animal modelBladder (BXF1299), pancreas (PAXF546), kidney (RXF944LX), colon (DLD-1, HT-29, TC37), central nervous system (SF-295), small cell lung (NCI-H69) and prostate (PC-3) xenografts. 
    Formulation & DosageDissolved in Sterile 0.9% sodium chloride solution; 10 mg/kg; i.p. injection 
    References

    Semin Oncol. 1989 Apr;16(2 Suppl 4):9-14; Eur J Cancer. 1999 Mar;35(3):512-20. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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