Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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500mg |
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1g |
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Other Sizes |
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Purity: ≥98%
Vinblastine (formerly NSC49842; NSC-49842; NSC 49842; Velban; Velsar; VLB; Vincaleukoblastine), a naturally occuring alkaloid isolated from the plant Vinca rosea Linn, is an approved anticancer drug acting as a potent mitotic inhibitor that inhibits microtubule assembly/formation. It has been approved for use in the treatment of various cancers. Vinblastine acts by binding to tubulin and inhibiting the formation of microtubule, thus leading to the disruption of mitotic spindle assembly and arrest of tumor cells in the G2/M phase of the cell cycle.
ln Vitro |
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ln Vivo |
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Animal Protocol |
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References |
Proc Soc Exp Biol Med.1993 Jul;203(3):372-6;Oncogene.2003 Sep 25;22(41):6458-61.
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Molecular Formula |
C46H58N4O9
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Molecular Weight |
810.97
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CAS # |
865-21-4
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Related CAS # |
865-21-4;143-67-9 (sulfate);
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SMILES |
[H][C@@]1(C2)C[C@](C(OC)=O)(C3=C(OC)C=C(N(C)[C@@]4([H])[C@](C(OC)=O)(O)[C@H](OC(C)=O)[C@@]5(CC)[C@@]6([H])[C@]47CCN6CC=C5)C7=C3)C8=C(CC[N@]2C[C@@](CC)(O)C1)C9=CC=CC=C9N8
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Chemical Name |
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.2331 mL | 6.1655 mL | 12.3309 mL | |
5 mM | 0.2466 mL | 1.2331 mL | 2.4662 mL | |
10 mM | 0.1233 mL | 0.6165 mL | 1.2331 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.