RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V1452 | Mercaptopurine (6-MP) | 50-44-2 | Mercaptopurine(also called 6-MP; 6-Thiohypoxanthine; 6-thiopurine;6-mercaptopurine; Purinethol) is an approved anticancer medication usedto treat malignancies. |
|
V1480 | Metronidazole | 443-48-1 | Metronidazole (trade names Flagyl, Metro, Trichopol, Vagilen), an imidazole-based and synthetic antibacterial and antiprotozoal drug belonging to the nitroimidazole class, is commonly used for the treatment of protozoa and other baterial infections. |
|
V2748 | Mirin | 1198097-97-0 | Mirin is a potent inhibitor of the MRN (Mre11 / Rad50 / Nbs1) complex and Ataxia Telangiectasia-Mutated (ATM) protein kinase. |
|
V1426 | Mitomycin C (Ametycine) | 50-07-7 | Mitomycin C(Mitozytrex; Mutamycin; Ametycine) is an antineoplastic antibiotic drug that acts by inhibiting DNA synthesis, and has been approved to treat different cancers. |
|
V1457 | Mizoribine (NSC 289637; HE 69) | 50924-49-7 | Mizoribine (also called Bredinin, HE-69; He69; NSC289637; NSC-289637) is an imidazole-based nucleoside isolated from the fungus Penicillium brefeldianum. |
|
V4019 | ML216 (CID-49852229) | 1430213-30-1 | ML216 (formerly known as CID-49852229) is a novel potent inhibitor of the Blooms syndrome protein (BLM) helicase which is responsible for DNA unwinding activity. |
|
V41179 | MMV688845 ((R)-GSK1729177A) | 2208962-35-8 | MMV688845 is a non-tuberculous mycobacterial RNA polymerase inhibitor (antagonist) with bactericidal ( bacteria killing) activity against Mycobacterium abscessus and anti-tuberculosis (TB) activity. |
|
V80805 | Moloney murine leukemia virus RT | Moloney murine leukemia virus RT is a monomeric reverse transcriptase derived from Moloney murine leukemia virus (MMLV). | |
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V55138 | Mulnitorsen | 2576358-63-7 | Mulnitorsen is an inhibitor (blocker/antagonist) of antisense non-coding mitochondrial RNA (ASncmtRNA) synthesis. |
|
V1438 | Mupirocin (BRL-4910A) | 12650-69-0 | Mupirocin (formerly BRL-4910A; BRL 4910A;Pseudomonic acid;Mupirocin, Bactroban, Centany) is a potent and orally bioactiveisoleucyl t-RNA synthetase inhibitor and a naturally occuring antibiotic isolated fromPseudomonas fluorescens. |
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V80917 | N-DMTr-Morpholino-T-5'-O-phosphoramidite | N-DMTr-Morpholino-T-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. | |
|
V80918 | N-DMTr-Morpholino-U-5'-O-phosphoramidite | N-DMTr-Morpholino-U-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. | |
|
V80919 | N-DMTr-N2-Isobutyryl-morpholino-G-5'-O-phosphoramidite | N-DMTr-N2-Isobutyryl-morpholino-G-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. | |
|
V80920 | N-DMTr-N4-Benzoyl-morpholino-cytosine-5'-O-phosphoramidite | N-DMTr-N4-Benzoyl-morpholino-cytosine-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. | |
|
V80921 | N-DMTr-N6-Benzoyl-morpholino-A-5'-O-phosphoramidite | N-DMTr-N6-Benzoyl-morpholino-A-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. | |
|
V52947 | N-Nitrosodiethylamine (Diethylnitrosamine; DEN) | 55-18-5 | N-Nitrosodiethylamine (Diethylnitrosamine) is a novel carcinogen dialkylnitrosamine. |
|
V56541 | N-Nitrosodiethylamine-d10 (Diethylnitrosamine-d10; DEN-d10) | 1219794-54-3 | N-Nitrosodiethylamine-d10 is the deuterated product of N-Nitrosodiethylamine. |
|
V56548 | N-Nitrosodiethylamine-d4 (Diethylnitrosamine-d4; DEN-d4) | 1346603-41-5 | N-Nitrosodiethylamine-d4 is the deuterated product of N-Nitrosodiethylamine. |
|
V55183 | N-Trityl-morpholino-T-5'-O-phosphoramidite | 2434654-73-4 | N-Trityl-morpholino-T-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
|
V55202 | N-Trityl-N2-isobutyryl-morpholino-G-5'-O-phosphoramidite | 2434795-03-4 | N-Trityl-N2-isobutyryl-morpholino-G-5'-O-phosphoramidite is a phosphoramidite monomer that may be utilized in the preparation /synthesis of oligonucleotides. |
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