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    Mupirocin (BRL-4910A)
    Mupirocin (BRL-4910A)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1438
    CAS #: 12650-69-0Purity ≥98%

    Description: Mupirocin (formerly BRL-4910A; BRL 4910A; Pseudomonic acid; Mupirocin, Bactroban, Centany) is a potent and orally bioactive isoleucyl t-RNA synthetase inhibitor and a naturally occuring antibiotic isolated from Pseudomonas fluorescens. It has been approved for use in the treatment of bacterial skin infections. Mupirocin is an antibiotic of the monoxycarbolic acid class. The effect of Mupirocin is concentration dependent, being bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. 

    References: J Antimicrob Chemother. 2015 Oct;70(10):2681-92; Nat Rev Microbiol. 2010 Apr;8(4):281-9.

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    Molecular Weight (MW)500.62 
    CAS No.12650-69-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (199.8 mM)
    Water: 46 mg/mL warmed (91.9 mM)
    Ethanol: 100 mg/mL (199.8 mM)
    Solubility (In vivo)

    Chemical Name: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid


    InChi Code: InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1

    SMILES Code: O=C(O)CCCCCCCCOC(/C=C(C)/C[[email protected]@H]1OC[[email protected]](C[[email protected]@H]2O[[email protected]]2[[email protected]]([[email protected]@H](O)C)C)[[email protected]@H](O)[[email protected]]1O)=O


    BRL4910A; Pseudomonic acid; BRL-4910A; BRL 4910A; Mupirocin, Bactroban, Centany

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    In Vitro

    In vitro activity: Mupirocin (BRL-4910A) shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin (BRL-4910A) is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum

    In VivoMupirocin is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A
    Animal modelN/A
    Formulation & Dosage

    [1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8.

    [2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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