My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Mupirocin (BRL-4910A)
    Mupirocin (BRL-4910A)

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1438
    CAS #: 12650-69-0Purity ≥98%

    Description: Mupirocin (formerly BRL-4910A; BRL 4910A; Pseudomonic acid; Mupirocin, Bactroban, Centany) is a potent and orally bioactive isoleucyl t-RNA synthetase inhibitor and a naturally occuring antibiotic isolated from Pseudomonas fluorescens. It has been approved for use in the treatment of bacterial skin infections. Mupirocin is an antibiotic of the monoxycarbolic acid class. The effect of Mupirocin is concentration dependent, being bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA. Mupirocin is a mixture of several pseudomonic acids, with pseudomonic acid A (PA-A) constituting greater than 90% of the mixture. 

    References: J Antimicrob Chemother. 2015 Oct;70(10):2681-92; Nat Rev Microbiol. 2010 Apr;8(4):281-9.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)500.62 
    FormulaC26H44O9 
    CAS No.12650-69-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (199.8 mM)
    Water: 46 mg/mL warmed (91.9 mM)
    Ethanol: 100 mg/mL (199.8 mM)
    Solubility (In vivo)

    Chemical Name: 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid

    InChi Key: MINDHVHHQZYEEK-HBBNESRFSA-N

    InChi Code: InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1

    SMILES Code: O=C(O)CCCCCCCCOC(/C=C(C)/C[[email protected]@H]1OC[[email protected]](C[[email protected]@H]2O[[email protected]]2[[email protected]]([[email protected]@H](O)C)C)[[email protected]@H](O)[[email protected]]1O)=O

    Synonyms

    BRL4910A; Pseudomonic acid; BRL-4910A; BRL 4910A; Mupirocin, Bactroban, Centany


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Mupirocin (BRL-4910A) shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin (BRL-4910A) is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum

    In VivoMupirocin is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A
    Animal modelN/A
    Formulation & Dosage
    References

    [1]. Sutherland R, et al. Antibacterial activity of mupirocin (pseudomonic acid), a new antibiotic for topical use. Antimicrob Agents Chemother. 1985 Apr;27(4):495-8.

    [2]. Parenti MA, et al. Mupirocin: a topical antibiotic with a unique structure and mechanism of action. Clin Pharm. 1987 Oct;6(10):761-70.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?