RNA synthesis, which is also called DNA transcription, is a highly selective process.Beyond RNA synthesis, RNA polymerase II transcription plays a more active role in the maturation, monitoring, and export of mRNA to the cytoplasm.
In order to fully repair the DNA after a single-strand break, DNA ligase constructs the final phosphodiester bond using the complementary strand of the double helix as a template.Substrates with RNA strands or mismatched base pairs near the ends of the nicked DNA are discriminated against by DNA ligases. Bleomycin (BLM) is a S-independent radiomimetic agent that damages DNA by creating free radicals that attack the C-4′ position in the deoxyribose backbone. This causes the ribose ring to open and strand breaks to occur.
M-MuLV Reverse Transcriptase (RNase H) and random hexamer primers are used to create first strand cDNA. The next step involves the use of DNA Polymerase I and RNase H to create second strand cDNA. Exonuclease/polymerase activity transforms the remaining overhangs into blunt ends. DNA fragments' 3′ ends are adenylated before being ligated with a NEBNext Adaptor with a hairpin loop structure to get the samples ready for hybridization. The two pathways that BET bromodomain inhibition most commonly affects are cell cycle and DNA replication. The translation of mRNA into proteins is inhibited by cycloheximide.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V51991 | Herboxidiene (GEX1A) | 142861-00-5 | Herboxidiene (GEX1A) is a potent phytotoxic polyketide derived from Streptomyces A7847 and has multiple activities, including herbicidal, anti-cholesterol, anti-tumor, etc. |
|
V56294 | HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt | 2641500-83-4 | HOE 33187-O-CONH-PEG4-phenol-thiophenone-NHPh-COOEt possesses inhibitory action on pre-miR-21 RNA. |
|
V53422 | Holomycin | 488-04-0 | Holomycin is a secondary metabolite of dithiopyrrolones. |
|
V1464 | Hydroxyurea (Hydroxycarbamide) | 127-07-1 | Hydroxyurea (formerly known as NCI-c04831, NSC-32065; NCIc04831, NSC32065; Biosupressin; Carbamoyl oxime; Droxia; Hydroxycarbamide) is an approved antineoplastic drug that has been used for treating various cancers such as melanoma, sickle-cell disease and resistant chronic myelocytic leukemia. |
|
V1445 | Ifosfamide | 3778-73-2 | Ifosfamide (formerly NSC-109724, Isophosphamide; Ifomide; Iphosphamid; iphosphamide; Isoendoxan; IsoEndoxan; Naxamide; Cyfos; Ifex; Ifosfamidum) is an approved anticancer medication which acts as a nitrogen mustard and DNA alkylating agent/alkylator. |
|
V51950 | IMP-1088 | 2059148-82-0 | IMP-1088 is a novel dual inhibitor of human N-myristoyltransferase NMT1 and NMT2 with IC50 of <1 nM for HsNMT1 and HsNMT2. |
|
V84747 | iPAF1C | 950403-60-8 | |
|
V34456 | Isopimpinellin | 482-27-9 | Isopimpinellin is an orally biologically active compound extracted from Glomerella cingulata. |
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V23533 | L189 | 64232-83-3 | L189 is a DNA ligase I, III and IV inhibitor (IC50 are 5, 9 and 5 μM respectively) that blocks DNA binding. |
|
V51888 | L82 | 329227-30-7 | L82 is a selective, non-competitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). |
|
V51887 | L82-G17 | 92285-87-5 | L82-G17 is a non-competitive DNA ligase I (Lig I) selective inhibitor. |
|
V51852 | Lomibuvir (VX-222) | 1026785-55-6 | Lomibuvir (VX-222) is a potent non-nucleoside polymerase inhibitor targeting thumb pocket 2 of the hepatitis C virus NS5B polymerase (RdRp) with a Kd of 17 nM. With an EC50 of 5.2 nM, Lomibuvir inhibits the HCV type 1b/Con1 subgenomic replicon. |
|
V80638 | Lurbinectedin-d3 (PM01183-d3; LY-01017-d3) | Lurbinectedin-d3 is the deuterated form of Lurbinectedin. | |
|
V76799 | m7GpppAmpG ammonium | m7GpppAmpG ammonium is a trinucleotide 5′ end cap analog that caps RNA with 90% efficiency. | |
|
|
V80658 | m7GpppGmpG ammonium | m7GpppGmpG ammonium is a trinucleotide 5′ cap analog. | |
|
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V80659 | m7Gpppm6AmpG ammonium | m7Gppm6AmpG ammonium is a trinucleotide mRNA 5' cap analog that can be used for in vitro RNA synthesis. | |
|
V24915 | Madrasin | 374913-63-0 | Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. |
|
V56545 | Maleic hydrazide-d2 (maleic hydrazide-d2; maleic hydrazide-d2) | 2398483-97-9 | Maleic hydrazide-d2 is the deuterated form of Maleic hydrazide. |
|
V1442 | Mechlorethamine HCl | 55-86-7 | Mechlorethamine HCl (chloramin; chlorethamine; mustine; HN2; Mustargen; and embikhin),the hydrochloride salt of Mechlorethamine, is the prototype of a class of anticancer chemotherapeutic drugs called DNA alkylators or DNA alkylating agents. |
|
V52998 | Mequindox | 13297-17-1 | Mequindox is a novel and seletive antibacterial agent. Mequindox inhibits the synthesis of DNA. |
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