A molecule known as a DNA alkylator or crosslinker can alkylate DNA or form a crosslink with DNA. The effects of a DNA alkylator or crosslinker can be mutagenic, therapeutic, or other. Transferring an alkyl group from one molecule to another is known as alkylation. The alkyl group can be transferred as a free radical, a carbanion, a carbene, or an alkyl carbocation.Alkyl groups are probably the most frequent group found in organic molecules, so alkylating agents are frequently used in chemistry. When there isn't a readily accessible biological precursor, selective alkylation—adding pieces of the chain with the desired functional groups—is used. Methylation is the name for alkylation with one carbon. Chemotherapy in medicine employs DNA alkylation to harm cancer cells' DNA. Alkylating antineoplastic agents are a class of medications that cause alkylation.When different exogenous or endogenous agents react with two different positions in the DNA, crosslinking of the DNA results. This can happen within the same strand of the DNA (intrastrand crosslink) or between the DNA strands (interstrand crosslink). Protein and DNA can crosslink with one another. Crosslinks prevent DNA from replicating, which stops replication and results in cell death if the crosslink is not repaired. The RAD51 family is involved in maintenance.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V23165 | KCC 07 | 315702-75-1 | KCC 07 is an MBD2 (Methyl-CpG-binding domain protein 2) inhibitor that prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. |
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V5123 | Lomustine (CCNU) | 13010-47-4 | Lomustine (also known as CCNU) is anitrosourea anticancer drug that belongs to the class of DNA alkylating agents. |
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V55756 | LP-284 | 2412580-47-1 | LP-284 is an effective agent for DNA alkylation that kills solid tumors. MCL, or mantle cell lymphoma, is one blood cancer that can be studied with LP-284 because it has poor DNA repair. |
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V34780 | Melphalan | 148-82-3 | Melphalan is an effective DNA alkylating agent (DNA alkylator) with anti-tumor activity. |
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V41073 | OBI-3424 (TH-3424) | 2097713-68-1 | OBI-3424 (TH-3424) is a precursor that is selectively converted to a potent DNA alkylating agent by AKR1C3 (aldehyde-keto reductase 1C3). |
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V4078 | Palifosfamide (ZIO-201) | 31645-39-3 | Palifosfamide (also known asIsophosphoramide mustard; IPM;ZIO201), a synthetic mustard compound and the active metabolite of ifosfamide, is a novel DNA alkylator with antitumor activity. |
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V34804 | Phosphoramide mustard | 10159-53-2 | Phosphoramide mustard is an anticancer agent that is a physiologically active metabolite of cyclophosphamide (HY-17420). |
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V34805 | Phosphoramide mustard cyclohexanamine | 1566-15-0 | Phosphoramide mustard cyclohexanamine is the active metabolite of cyclophosphamide (Cyclophosphamide.html" target="_blank" style="color: #6a4b92; font-weight:bold;">HY-17420) and has anti-tumor activity. |
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V8192 | Pipobroman | 54-91-1 | Pipobroman is a brominated analogue of piperazine and an effective alkylating agent. |
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V40984 | PR-104 sodium | 851627-80-0 | PR-104 (sodium) is a selective hypoxia-activated DNA cross-linker that can be used in research on a variety of tumor xenograft models. |
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V3530 | Satraplatin | 129580-63-8 | Satraplatin (formerly JM-216; BMS-182751; JM216; BMS182751) is a DNA alkylating agent and the firstoral platinum analog with antitumor activity. |
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V55755 | Tesirine intermediate-1 | 1430738-05-8 | Tesirine intermediate-1 is an intermediate of Tesirine (HY-128952). |
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V54753 | Tesirine intermediate-2 | 1430738-34-3 | Tesirine intermediate-2 is an intermediate of Tesirine (HY-128952). |
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V5077 | Treosulfan (NSC-39069; Treosulphan) | 299-75-2 | Treosulfan (NSC 39069; Treosulphan) is a novel and potent DNA alkylating agent with activity in ovarian cancer and other solid tumor types. |
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V10141 | Tretazicar (CB 1954) | 21919-05-1 | Tretazicar (CB-1954; CB1954),a dinitrobenzamide analog and prodrug, is a potent and highly selective DNA alkylating agent that generates highly cytotoxic interstrand crosslinks in DNA. |
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