Microtubules are a component of the cytoskeleton, found throughout the cytoplasm.These highly dynamic tubular tubulin polymers have an average length of 25 m and a maximum growth length of 50 micrometers. A microtubule has an inner diameter of 12 nm and an outer diameter of about 24 nm. Alpha and beta tubulin combine to form a dimer, which is then polymerized to form microtubules, which are found in eukaryotic cells. One of many members of a small family of globular proteins is tubulin.The alpha-, beta-, gamma-, delta-, and epsilon-tubulins are among the five distinct families that make up the tubulin superfamily, and a sixth family is only found in kinetoplastid protozoa. The proteins that make up microtubules, -tubulin and -tubulin, are the most prevalent members of the tubulin family. Microtubules play a crucial role in many cellular processes. They assist in keeping the cell's structure intact.
| Structure | Cat No. | Product Name | CAS No. | Product Description |
|---|---|---|---|---|
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V81734 | Vincristine-d6 sulfate (Leurocristine-d6 (sulfate); NSC-67574-d6 (sulfate); 22-Oxovincaleukoblastine-d6 (sulfate)) | Vincristine-d6 (sulfate) is the deuterated form of Vincristine sulfate. | |
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V88705 | Vinzolidine | 67699-40-5 | Vinzolidine is a semisynthetic vinca alkaloid. |
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V35137 | Violanone | 52250-38-1 | Violanone is an isoflavanone compound that can inhibit tubulin polymerization. |
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V53954 | Wikstrol A | 159736-35-3 | Wikstrol A is a potent antifungal, antimitotic, and anti-HIV-1 agent. |
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V19682 | MMAF (Monomethyl auristatin F) | 745017-94-1 | Monomethyl auristatin F (also known as MMAF) is a highly potent tubulin/antimitotic inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. |
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V1887 | Monomethyl auristatin E (MMAE) | 474645-27-7 | Monomethyl auristatin E (also known as MMAE; SGD-1010), adolastatin 10 derivative, is a novel, synthetic and potent antimitotic/antitubulin agent which blocks the polymerization of tubulin,due to its high toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. |
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V3514 | Ixabepilone | 219989-84-1 | Ixabepilone (formerly known as azaepothilone B and BMS-247550; Trade name: Ixempra)is a potent and orally bioavailable microtubule-stabilizing agent for the treatment of cancer. |
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V18816 | Crolibulin | 1000852-17-4 | Crolibulin, formerly known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity. |
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V22543 | Indibulin | 204205-90-3 | Indibulin is a synthetic small molecule with antimitotic and potential antineoplastic activities. |
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V32040 | Deoxypodophyllotoxin | 19186-35-7 | Deoxypodophyllotoxin (DPT), an analogue of podophyllotoxin, is a lignan extracted from Anthriscus sylvestris with potent antimitotic and antiviral properties. |
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V3524 | Epothilone D (KOS 862) | 189453-10-9 | Epothilone D (formerly known as KOS 862; KOS-862; desoxyepothilone B) is a potent microtubule stabilizing agent that has high anticancer activity. |
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V7586 | Taltobulin | 228266-40-8 | Taltobulin (HTI-286; SPA-110), an analog of the natural tripeptide hemiasterlin, is a tubulin inhibitor with anticancer activity. |
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V26884 | Ombrabulin HCl | 253426-24-3 | Ombrabulin HCl (AV-E8062;AC-7700;AVE8062), an analogue of combretastatin A4 with improved water solubility, is a novel and potent tubulin inhibitor andvascular-disrupting agent with anticancer activity. |
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V29720 | Ansamitocin P-3 (Antibiotic C 15003P3'; Maytansinol butyrate) | 66584-72-3 | Ansamitocin P-3 (Maytansinol isobutyrate; NSC-292222;Antibiotic C 15003P3) is a potent microtubule/antimitotic inhibitor used as an warhead of ADC (antibody drug conjugate). |
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V51606 | Ansamitocin analog (20-O-Demethyl-AP3) | 72902-38-6 | Ansamitocin analog (20-O-Demethyl-AP3) is one of ansamitocin P-3's minor metabolites. |
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V51024 | Combretastatin A-1 | 109971-63-3 | Combretastatin A-1 is a novel inhibitor of microtubule polymerization that attaches itself to tubulin's colchicine-binding site. |
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V39080 | Tubulin inhibitor 6 | 105925-39-1 | Tubulin inhibitor 6 (Compound 14b) is a novel and potent tubulin inhibitor (mitotic inhibitor or tubulin destabilizer) with anticancer activity. |
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V32229 | MMAF sodium | 1799706-65-2 | Monomethyl auristatin F (MMAF) sodium is a highly potent tubulin inhibitor and an antineoplastic agent used as a warhead in ADCs (antibody-drug conjugates) such as vorsetuzumab mafodotin and SGN-CD19A. |
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V20351 | Vinblastine sulfate (NSC49842) | 143-67-9 | Vinblastine sulfate (also known as NSC49842; Vincaleukoblastine), a natural alkaloid extracted from the plant Vinca rosea Linn, is an approved anticancer drug and a potent mitotic inhibitor that inhibits microtubule formation and suppresses nAChR activity with IC50 of 8.9 μM in a cell-free assay, it is used to treat certain kinds of cancer. |
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V3117 | Colchicine | 64-86-8 | Colchicine (Colchicina; Condylon; Colsaloid; Colchicinum) is a mitotic/tubulin inhibitor that inhibits microtubule polymerization (also called microtubule disrupting agent or tubulin inhibitor) with potential anticancer and anti-inflammatory effects. |
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