Size | Price | Stock | Qty |
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10mg |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Tubulin inhibitor 6 (Compound 14b) is a novel and potent tubulin inhibitor (mitotic inhibitor or tubulin destabilizer) with anticancer activity. Tubulin polymerization is inhibited with an IC50 of 0.87 μM. K562 cell growth is inhibited by tubulin inhibitor 6 at an IC50 of 840 nM.
Targets |
tubulin polymerization (IC50 = 0.87 μM)
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ln Vitro |
Tubulin inhibitor 6 exhibits antiproliferative activity at submicromolar levels[1].
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References |
Molecular Formula |
C20H14NO2SCL
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Molecular Weight |
367.84866
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Exact Mass |
367.04
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Elemental Analysis |
C, 65.30; H, 3.84; Cl, 9.64; N, 3.81; O, 8.70; S, 8.72
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CAS # |
105925-39-1
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Related CAS # |
105925-39-1
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Appearance |
Solid powder
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SMILES |
COC1=CC=C(C=C1)C(=O)N2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl
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InChi Key |
CSWHYHPUEDNIQY-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C20H14ClNO2S/c1-24-15-9-6-13(7-10-15)20(23)22-16-4-2-3-5-18(16)25-19-11-8-14(21)12-17(19)22/h2-12H,1H3
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Chemical Name |
(2-chlorophenothiazin-10-yl)-(4-methoxyphenyl)methanone
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Synonyms |
Tubulin inhibitor 6; iHAP1; CUN25391; CUN 25391; CUN-25391
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO: 20~62.5 mg/mL (54.4~169.9 mM)
Ethanol: ~5 mg/mL (~13.6 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 6.25 mg/mL (16.99 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 62.5 mg/mL clear DMSO stock solution to 900 μL corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.7185 mL | 13.5925 mL | 27.1850 mL | |
5 mM | 0.5437 mL | 2.7185 mL | 5.4370 mL | |
10 mM | 0.2718 mL | 1.3592 mL | 2.7185 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.